Retinal artery occlusion and the 3-year risk of stroke in taiwan: a nationwide population-based study.
ABSTRACT To verify the association between retinal artery occlusion (RAO) and stroke with a large-scale nationwide study.
Retrospective nationwide population-based administrative database study.
Data were collected from the Longitudinal Health Insurance Database 2000 (LHID2000), which contains claim data from 1 million randomly selected beneficiaries among Taiwan's 23 million residents. The study cohort consisted of all patients with a diagnosis of RAO from January 1999 through December 2006 (n = 464). The control group consisted of randomly selected patients (n = 2748) matched with the study group by age, sex, date of index medical care, and comorbid hypertension. Patients were tracked from their index date for 3 years. The Kaplan-Meier method was used to compute the stroke-free survival rate. Cox proportional hazard regressions were used to compute the adjusted stroke-free survival rate after adjusting for possible confounding factors.
Ninety-one RAO patients (19.61%) and 280 controls (10.05%) had a stroke (P < .0001) during the 3-year follow-up period. Compared with the controls, the incidence rate ratios of stroke in RAO patients were 9.46 at 0-1 month, 5.57 at 1-6 months, and 2.16 at 0-3 years after RAO (P < .0001). After adjusting for age, sex, and selected comorbid disorders, the hazard ratio of having a stroke for RAO patients was still 2.07 times higher than that of controls and 3.34 times higher in the ≤60-year-old subgroup.
RAO increases the risk for subsequent stroke. Early neurologic evaluation and secondary prevention for stroke are recommended for RAO patients.
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ABSTRACT: To define the incidence and demographics of clinically diagnosed central retinal artery occlusion (CRAO) in Korea.Ophthalmology 06/2014; · 6.17 Impact Factor
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ABSTRACT: Purpose: To report a case of branch retinal artery occlusion (BRAO) in a pregnant patient of Chinese descent found to have Protein S deficiency. Case report: A 35 year-old apparently healthy, pregnant female of Chinese origin reported in the eye clinic of our hospital with a complaint of sudden appearance of a "shadow" in the periphery of her left eye for the last three days. On examination, she was found to have a BRAO in that eye. A number of laboratory, radiological and systemic examinations were done to find out the cause of the occlusion. However, a deficiency of Protein S was the only abnormality found. So far there have been only a few cases reported concerning this hematological deficiency causing a BRAO. This case report describes the events leading to the diagnosis of this rare condition. Conclusion: In cases of BRAO, especially in young patients it is important to rule out Protein S deficiency which may have life-threatening consequences.Journal of Medical Case Reports 09/2014; 2(2):175-180.
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