Article

[Relationship between serum S100B protein level and brain damage in preterm infants].

Department of Pediatrics, Xinhua Hospital of Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 07/2012; 14(7):485-8. pp.485-8
Source: PubMed

ABSTRACT To study changes of serum S100B protein level in preterm infants with brain damage and its role.
Forty-seven preterm infants were classified into 3 groups based on the results of brain ultrasound and MRI: brain white matter damage (WMD; n=13), brain but not white matter damage (non-WMD; n=14) and control (no brain damage; n=20). Blood samples were collected within 24 hrs, 72 hrs and 7 days after birth. S100B protein level was measured using ELISA.
Serum levels of S100B in the WMD and non-WMD groups were significantly higher than in the control group within 24 hours, 72 hours and 7 days after birth (P<0.05). More increased serum S100B levels were observed in the WMD group compared with the non-WMD group (P<0.05).
Serum S100B protein level increases in preterm infants with brain damage within 7 days after birth, suggesting that it may be used as an early sensitive marker for the diagnosis of brain damage, especially WMD.

0 0
 · 
0 Bookmarks
 · 
26 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

3 groups
 
7 days
 
Blood samples
 
brain damage
 
brain ultrasound
 
brain white matter damage
 
control group
 
MRI
 
non-WMD
 
non-WMD group
 
non-WMD groups
 
preterm infants
 
S100B protein level
 
sensitive marker
 
Serum levels
 
serum S100B levels
 
serum S100B protein level
 
Serum S100B protein level increases
 
study changes
 
white matter damage