Toxic hepatitis in a group of 20 male body-builders taking dietary supplements
ABSTRACT Dietary supplements have been used for decades for enhancing muscle growth. The harm caused by some of these products is well documented. We investigated and reported toxic hepatitis in 20 male athletes following self-prescribing of a number of dietary supplements which are lesser known. The patients' ages ranged from 24 to 32 with a mean of 28years. They had taken three kinds of supplements for 1year including testosterone optimizer agent T Bomb II, a creatine supplement Phosphagen and an amino acid based supplement Cell-Tech. Based on the history, clinical examination, and laboratory findings the cases were diagnosed as toxic hepatitis. After discontinuation of taking the supplements, clinical recovery and improvement of liver function tests were achieved within 30days. Causality assessment with the CIOMS (Council for International Organization Medical Sciences) scale showed a "possible" grade of causality (+5 points) for these supplements. It can be concluded that these newer anabolic supplements may induce toxic hepatitis. Since the health risks of them may be severe, the use of these kinds of dietary supplements should be discouraged.
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ABSTRACT: Hepatitis associated aplastic anemia (HAAA) is a rare syndrome in which severe aplastic anemia (SAA) complicates the recovery of acute hepatitis (AH). HAAA is described to occur with AH caused by viral infections and also with idiopathic cases of AH and no clear etiology of liver injury. Clinically, AH can be mild to fulminant and transient to persistent and precedes the onset SAA. It is assumed that immunologic dysregulation following AH leads to the development of SAA. Several observations have been made to elucidate the immune mediated injury mechanisms, ensuing from liver injury and progressing to trigger bone marrow failure with the involvement of activated lymphocytes and severe T-cell imbalance. HAAA has a very poor outcome and often requires bone marrow transplant (BMT). The findings of immune related myeloid injury implied the use of immunosuppressive therapy (IST) and led to improved survival from HAAA. We report a case of young male who presented with AH resulting from the intake of muscle building protein supplements and anabolic steroids. The liver injury slowly resolved with supportive care and after 4 months of attack of AH, he developed SAA. He was treated with IST with successful outcome without the need for a BMT.01/2014; 2014:216570. DOI:10.1155/2014/216570
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ABSTRACT: Nutrition plays a pivotal role in sustaining human health, extending healthy life span, enhancing sports performance, and offsetting the challenges of advancing age. As current research improves our understanding of dietary requirements in different contexts of human function, a comprehensive appraisal of the role of nutrition in human health and performance is warranted. It is this need that has inspired the current volume. This volume is divided into six thematic sections. The introductory section presents a general overview of the role of nutrition in human health. This section is a compilation of chapters reviewing nutritional prophylaxis in human health, including food exchange values, personalized nutrition and a critical assessment of antioxidants, vitamins, membrane stabilizers, minerals, herbal extracts and other nutritional supplements and their influence on human health and exercise performance. This section also addresses performance enhancement drugs and sports supplements, discussing concerns associated with the benefits and risks associated with the use of performance-enhancing supplements.Nutrition and Enhanced Sports Performance, Muscle Building, Endurance, and Strength, Edited by Debasis Bagchi, Nair Sreejayan and Chandan K. Sen, 08/2013: chapter Performance Enhancement Drugs and Sports: pages 151-159; Academic Press., ISBN: 978-0-12-396454-0
Alimentary Pharmacology & Therapeutics 02/2015; 41(3). DOI:10.1111/apt.13048 · 4.55 Impact Factor