Article

New cleavable isocyanides for the combinatorial synthesis of α-amino acid analogue tetrazoles

Tetrahedron Letters (impact factor: 2.68). 09/2005; 46:7393-7396. DOI:10.1016/j.tetlet.2005.08.101 pp.7393-7396

ABSTRACT 3-Substituted 3-isocyano propionates as new cleavable isocyanides in combinatorial tetrazole synthesis via Ugi-reaction are introduced. The obtained 5-substituted tetrazoles are transformed into carboxylic acid isosteric 5-substituted 1H-tetrazoles under basic cleavage conditions.

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