Article

The molecular determinants of CD8 co-receptor function.

Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.
Immunology (impact factor: 3.32). 07/2012; 137(2):139-48. DOI:10.1111/j.1365-2567.2012.03625.x pp.139-48
Source: PubMed

ABSTRACT CD8(+) T cells respond to signals mediated through a specific interaction between the T-cell receptor (TCR) and a composite antigen in the form of an epitopic peptide bound between the polymorphic α1 and α2 helices of an MHC class I (MHCI) molecule. The CD8 glycoprotein 'co-receives' antigen by binding to an invariant region of the MHCI molecule and can enhance ligand recognition by up to 1 million-fold. In recent years, a number of structural and biophysical investigations have shed light on the role of the CD8 co-receptor during T-cell antigen recognition. Here, we provide a collated resource for these data, and discuss how the structural and biophysical parameters governing CD8 co-receptor function further our understanding of T-cell cross-reactivity and the productive engagement of low-affinity antigenic ligands.

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Keywords

CD8 co-receptor
 
CD8 co-receptor function
 
CD8 glycoprotein 'co-receives' antigen
 
collated resource
 
composite antigen
 
epitopic peptide
 
low-affinity antigenic ligands
 
MHC class
 
productive engagement
 
recent years
 
specific interaction
 
structural
 
T-cell antigen recognition
 
T-cell cross-reactivity
 
T-cell receptor
 
TCR
 
α2 helices