Article

Surface-modified protein nanospheres as potential antiviral agents.

Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan 52900, Israel.
Chemical Communications (impact factor: 6.17). 07/2012; 48(67):8359-61. DOI:10.1039/c2cc33448h pp.8359-61
Source: PubMed

ABSTRACT A novel application of surface-modified protein nanospheres as potential antiviral agents is illustrated. By using a single-step sonochemical process, bovine serum albumin nanospheres were generated, whose surface was covalently conjugated with mercaptoethane sulfonate to chemically and electrostatically mimic cellular heparan sulfate. The nanospheres effectively inhibited HSV-1 infection.

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Keywords

bovine serum albumin nanospheres
 
chemically
 
nanospheres
 
potential antiviral agents
 
single-step sonochemical process
 
surface-modified protein nanospheres