Article

Liquid chromatography and mass spectrometry of haem biosynthetic intermediates: a review.

Clinical Biochemistry, King's College Hospital, Denmark Hill, London, SE5 9RS, UK.
Biomedical Chromatography (impact factor: 1.97). 08/2012; 26(8):1009-23. DOI:10.1002/bmc.2772
Source: PubMed

ABSTRACT This article discusses the separation, analysis and characterisation of intermediates and oxidative by-products of the haem biosynthetic pathway by liquid chromatography and mass spectrometry. Techniques reviewed include high-performance liquid chromatography, ultra-high-performance liquid chromatography, capillary electrophoresis, ion mobility spectrometry, mass spectrometry and tandem mass spectrometry. The emphasis was on the analysis of biological and clinical samples.

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Keywords

article discusses
 
biological
 
capillary electrophoresis
 
haem biosynthetic pathway
 
high-performance liquid chromatography
 
intermediates
 
liquid chromatography
 
mass spectrometry
 
tandem mass spectrometry
 
ultra-high-performance liquid chromatography
 

Christopher M Benton