Article

Human Seminal Plasma Fosters CD4(+) Regulatory T-cell Phenotype and Transforming Growth Factor-β1 Expression.

Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
American Journal Of Reproductive Immunology (impact factor: 2.17). 07/2012; 68(4):322-30. DOI:10.1111/j.1600-0897.2012.01176.x
Source: PubMed

ABSTRACT Semen mediates expansion of CD4(+) regulatory T cells (Treg) in the murine female reproductive tract. The impact of semen on Treg in humans, however, remains unclear.
Using seminal plasma (SP) from 20 healthy donors, we investigated the impact of human semen on CD4(+) T-cell expression of CD127 and CD49d as well as CD4(+) CD127(low) CD49d(low) Treg proliferation, apoptosis, and intracellular expression of FoxP3, TGF-β1, and IL-10.
SP reduced CD4(+) T-cell expression of CD127 and CD49d and increased the proportion of CD127(low) CD49d(low) Treg. This increase was non-proliferative, mediated in part via the conversion of CD4(+) helper T cells into FoxP3(-) but not FoxP3(+) Treg. Additionally, SP induced an increase in intracellular expression of the immunosuppressive cytokine TGF-β1 by the FoxP3(-) but not FoxP3(+) Treg. SP had no impact on Treg intracellular expression of IL-10.
Human seminal plasma fosters the non-proliferative increase in the proportion and immunoregulatory activity of FoxP3(-) Treg.

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Keywords

20 healthy donors
 
FoxP3
 
human semen
 
humans
 
immunoregulatory activity
 
immunosuppressive cytokine TGF-β1
 
intracellular expression
 
murine female reproductive tract
 
non-proliferative increase
 
semen
 
Semen mediates expansion
 
seminal plasma
 
SP
 
TGF-β1
 
Treg
 
Treg intracellular expression
 

Emmanuel Balandya