Lack of 'appropriately assessed' patient-reported outcomes in randomized controlled trials assessing the effectiveness of interventions for rosacea

Department of Dermatology, B1-Q, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, the Netherlands U.K. Cochrane Centre (Bahrain Branch), College of Medicine, AMA International University of Bahrain, Awali, Bahrain E-mail: .
British Journal of Dermatology (Impact Factor: 4.28). 07/2012; 168(2). DOI: 10.1111/j.1365-2133.2012.11148.x
Source: PubMed


Rosacea is a chronic skin disease and psychological problems are fairly common in people affected by rosacea. The persistent red pimply rash on the face can be a source of embarrassment, anxiety and low self-esteem, may instil a lack of confidence and may even lead to depression or body dysmorphic disorder. Rosacea can also have a significant negative impact on health-related quality of life (HRQoL).We have documented the patient-reported outcomes (PRO) used in clinical trials identified in the Cochrane Review on the effectiveness of interventions for rosacea published in the Cochrane Library March 2011 and reported their measurement properties.(1) Here we discuss the results.

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    ABSTRACT: Background: Rosacea is a common problem that is underdiagnosed; if left untreated can result in physical disfigurement and emotional distress. Objective: We reviewed the current literature to determine the degree of psychosocial impact of rosacea and the importance of treatment. We also reviewed the current treatment options. Methods: A search of the MEDLINE, EMBASE, and psycINFO databases from 1946 to present was performed to identify previous articles regarding the psychosocial and quality-of-life (QoL) impact of rosacea. Results: A total of 17 studies were found that focused on the following areas: impact of disease on QoL, improvement of QoL with treatment, and willingness to pay. Limitations: Reviewed articles used different measurement systems to quantify impact on QoL making comparisons between studies difficult to interpret. Conclusion: Patients with rosacea have higher incidences of embarrassment, social anxiety, depression, and decreased QoL compared with the rest of the population. Adequate treatment of symptoms results in improvement of QoL in patients with rosacea. New options that target the facial erythema of rosacea may help mitigate the negative psychological impact of rosacea.
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