Article
Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection.
Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.
Nature Chemical Biology (impact factor:
14.69).
07/2012;
8(9):745-7.
DOI:10.1038/nchembio.1023
Source: PubMed
- Citations (15)
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Cited In (0)
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Article: Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells.
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Article: Salmonella-Induced Caspase-2 Activation in Macrophages: A Novel Mechanism in Pathogen-Mediated Apoptosis
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ABSTRACT: The enterobacterial pathogen Salmonella induces phagocyte apoptosis in vitro and in vivo. These bacteria use a specialized type III secretion system to export a virulence factor, SipB, which directly activates the host's apoptotic machinery by targeting caspase-1. Caspase-1 is not involved in most apoptotic processes but plays a major role in cytokine maturation. We show that caspase-1–deficient macrophages undergo apoptosis within 4–6 h of infection with invasive bacteria. This process requires SipB, implying that this protein can initiate the apoptotic machinery by regulating components distinct from caspase-1. Invasive Salmonella typhimurium targets caspase-2 simultaneously with, but independently of, caspase-1. Besides caspase-2, the caspase-1–independent pathway involves the activation of caspase-3, -6, and -8 and the release of cytochrome c from mitochondria, none of which occurs during caspase-1–dependent apoptosis. By using caspase-2 knockout macrophages and chemical inhibition, we establish a role for caspase-2 in both caspase-1–dependent and –independent apoptosis. Particularly, activation of caspase-1 during fast Salmonella-induced apoptosis partially relies on caspase-2. The ability of Salmonella to induce caspase-1–independent macrophage apoptosis may play a role in situations in which activation of this protease is either prevented or uncoupled from the induction of apoptosis.Journal of Experimental Medicine 11/2000; · 13.85 Impact Factor
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Keywords
activity-based probe
apoptosis
bypass apoptosis
caspase-1 activation
primary mouse bone marrow macrophages
Salmonella enterica var
Salmonella infection
Typhimurium infection
