Protective Mechanisms of Green Tea Polyphenols in Skin

Department of Dermatology, University Hospitals Case Medical Center, Cleveland, OH 44106-5028, USA.
Oxidative Medicine and Cellular Longevity (Impact Factor: 3.36). 06/2012; 2012:560682. DOI: 10.1155/2012/560682
Source: PubMed

ABSTRACT Skin is frequently exposed to a variety of environmental, chemical, and genotoxic agents that contribute to disease and carcinogenesis. Ultraviolet light (UVR) is the main external stress that leads to immunosuppression, oxidative stress, premature aging, and tumor formation. Scientists and health professionals emphasize the importance of prevention strategies to circumvent such unfavorable outcomes. Plant polyphenols are a promising approach to disease prevention and treatment. Green tea is an abundant source of plant polyphenols that exhibit significant antioxidant, chemopreventive, and immunomodulatory effects in protecting the skin.

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    ABSTRACT: The skin is the largest organ of the body with a surface area of approximately 1.5–2.0 m2. It protects the internal organs of the body by acting as an effective barrier against the detrimental effects of environmental and xenobiotic agents (e.g., extrinsic harmful chemicals and genotoxics). Strong or chronic exposition to a variety of external stresses (e.g., ultraviolet radiation aka solar UV) may contribute to premature skin aging, immune-suppression, and tumorigenesis/carcinogenesis (i.e. tumor/cancer formation). Therefore, a search for prevention strategies to circumvent such unfavorable outcomes is being constantly pursued. Polyphenols (aka polyhydroxyphenols) represent a superfamily of diverse naturally occurring phytochemicals. An increasing number of studies on vertebrates and invertebrates have shown that these compounds modulate many signaling pathways, and subsequently exert numerous biological activities (e.g., significant antioxidant, chemopreventive, immune-modulatory, cell repair and photo-protective effects) as well as potential health benefits (e.g., prevention of aging, reduction in cancer incidences and other inflammatory-state diseases). Among the several hundreds of dietary polyphenols (plant nutraceuticals aka phytonutrients), some constitute a promising approach to remedying many skin conditions (i.e., prevention and treatment of skin aging and diseases). The protective skin aging effects exhibited by polyphenols may, however, partially depend on their molecule characteristics, the food matrix, and/or on their bioavailability, which does not always depend on the overall intake/consumption. Eventually, natural purified polyphenols or polyphenol-rich plant extracts (semi-synthetic or synthetic) might supplement skin chemotherapeutics, our sun protection armamentarium, and further enhance the benefit of esthetic techniques (e.g., microdermabrasion). Thereby, polyphenols are also gaining popularity as ingredients in cosmetic formulations (cosmeceuticals). In this chapter, we outline the current progress in skin aging intervention studies using polyphenols (e.g., purified polyphenols, dietary, or topical rich-polyphenols products).
    Polyphenols in Human Health and Disease, Edited by Watson, Ronald Ross and Preedy, Victor R and Zibadi, Sherma, 01/2014: pages 819-830; Academic Press., ISBN: 9780123984562
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    ABSTRACT: Several studies have confirmed dramatic changes in skin surface parameters during the winter months. Although there are many studies supporting the positive effects of topical treatment, there are no published studies demonstrating the effects of oral supplementation in the prevention of negative skin changes during winter. The purpose of this study was to evaluate the efficacy of an oral micronutrient supplement in preventing the negative effects of winter weather on skin quality using noninvasive biometrologic instruments. This study included 80 healthy female volunteers aged 35-55 years with phototype II-IV skin. Randomization was balanced. Two tablets of a micronutrient supplement (Perfectil® Platinum) or placebo were administered once daily for 4 months. The volunteers were examined at baseline, after 4 months, and 6 weeks after termination of treatment (month 5.5). The evaluation included skin microrelief by Visioscan® as the main outcome, and the secondary outcomes were results on standard macrophotography, skin tension by Reviscometer®, skin high-frequency ultrasound, and self-assessment. For all pseudoroughness and microrelief indicators, there was a significant increase from baseline to month 4 in the placebo group (P<0.05) but no change in the active group. Descriptive statistics for the mean minimum, mean maximum, and minimum to maximum ratio on the nonexposed study zone showed a significant and dramatic difference between baseline and month 4 and between baseline and month 5.5 (P<0.05) in the active group, indicating decreasing anisotropy of the skin. High-frequency ultrasound on the exposed study zone revealed that skin thickness was significantly decreased in the placebo group during winter but was stable in the treated group (P<0.01). The photography scaling and self-assessment questionnaire revealed no significant changes in either group. These results indicate that the skin is prone to seasonal changes during winter, particularly in exposed areas. The data also indicate that oral supplementation can be a safe treatment, with no serious side effects, and may prevent or even eliminate the negative effects of winter on the skin.
    Clinical Interventions in Aging 01/2013; 8:1527-1537. DOI:10.2147/CIA.S43976 · 1.82 Impact Factor
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    ABSTRACT: Effects of post-treatment of laver extract on UVB-exposed HaCaT cells were examined.•Laver extract caused increases in both net cell viability and apoptotic fractions.•Laver extract caused increase in GSH/GSSG ratio and decrease in glutathione content.•Laver extract enhanced UVB-induced phosphorylation of JNK and ERK.
    Journal of Photochemistry and Photobiology B Biology 11/2014; DOI:10.1016/j.jphotobiol.2014.10.012 · 2.80 Impact Factor

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