Hepatosplenic and Muscular Sarcoidosis: Characterization with MR Imaging

Department of Radiology, Nippon Medical School, Tokyo, Japan.
Magnetic Resonance in Medical Sciences (Impact Factor: 1.48). 07/2012; 11(2):83-9. DOI: 10.2463/mrms.11.83
Source: PubMed


Sarcoidosis is a multisystem disorder of unknown etiology that involves multiple organs. Computed tomography is the first-line imaging modality for diagnosing sarcoidosis because of its capacity to detect hilar lymphadenopathy and pulmonary lesions. Magnetic resonance (MR) imaging provides good soft tissue contrast that is useful for detecting sarcoidosis in some body parts, including skeletal muscle. Signal intensity on pre- and postcontrast T(1)- and T(2)-weighted imaging may reflect disease activity and the pathological appearance of sarcoidosis. In this review, we demonstrate these conventional MR imaging findings of hepatosplenic and muscular sarcoidosis and describe the usefulness of diffusion-weighted imaging for detecting sarcoidosis.

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    • "The higher prevalence of musculoskeletal clinical manifestations in the present study could be explained by racially dependent pevalence of arthritis (5). As in other studies, acute arthritis of sarcoidosis was more common in the ankles, knees, and wrists (7, 15). Oligoarthritis was more common than polyarthritis and the pattern of arthritis was symmetric and additive in all patients. "
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    ABSTRACT: Background:Sarcoidosis is a multisystem disease affecting different organs with different frequency rates depending on geographical location. Musculoskeletal abnormalities includes osseous lesions (small and large bone sarcoidosis), sarcoidal arthropathy, and sarcoidal myopathy. Musculoskeletal involvement is reported in a significant number of patients.Objectives:This study aimed to determine the prevalence and clinical picture of musculoskeletal sarcoidosis in Iranian cohort of patients with sarcoidosis.Patients and Methods:We designed a descriptive cross-sectional study including 30 patients with sarcoidosis who had hospitalized in the Rheumatology Department at Ghaem Hospital, Mashhad, Iran. The patients were evaluated for musculoskeletal symptoms using history, physical examination, and paraclinical data.Results:Of the 30 studied patients, 24 were female (80%) and six were male (20%). The mean age at diagnosis was 38 years. Sarcoidal arthropathy (arthritis and periarthritis) was observed in 26 patients (86.6%). Furthermore, the initial presentation was associated with joint symptoms in 19 cases (63.3%); acute arthritis developed in 17 (65%) while bone and muscle involvements each occurred in 2 (6.6%).Conclusions:Sarcoidosis is a common disease in women aged 20 to 40 years. The most common involved joint were consecutively ankles, knees, and wrists, reaching a accumulated frequency of 86.6%; however, bone and muscle involvements were uncommon.
    07/2014; 16(7):e17918. DOI:10.5812/ircmj.17918
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    • "Sarcoidosis is a granulomatous systemic disease of unknown etiology that may involve several organs and not infrequently the spleen. Of patients with systemic sarcoidosis, 24 to 59% have biopsy-documented splenic sarcoidosis [17]. "
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    ABSTRACT: Despite being well visualized by different cross-sectional imaging techniques, the spleen is many times overlooked during the abdominal examination. The major reason is the low frequency of splenic abnormalities, the majority consisting of incidental findings. There has been a steady increase in the number of performed abdominal magnetic resonance imaging (MRI) studies; therefore, it is important to be familiar to the major MRI characteristics of disease processes involving the spleen, in order to interpret the findings correctly, reaching whenever possible the appropriate diagnosis. The spleen may be involved in several pathologic conditions like congenital diseases, trauma, inflammation, vascular disorders and hematologic disorders, benign and malignant tumors, and other disease processes that focally or diffusely affect the spleen. This paper presents a description and representative MRI images for many of these disorders.
    11/2013; 2013(2):219297. DOI:10.1155/2013/219297

  • American Journal of Roentgenology 02/2004; 182(1):15-28. DOI:10.2214/ajr.182.1.1820015 · 2.73 Impact Factor
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