Stabilization of vaccines and antibiotics in silk and eliminating the cold chain.

Tufts University, Department of Biomedical Engineering, Medford, MA 02155, USA.
Proceedings of the National Academy of Sciences (Impact Factor: 9.81). 07/2012; 109(30):11981-6. DOI: 10.1073/pnas.1206210109
Source: PubMed

ABSTRACT Sensitive biological compounds, such as vaccines and antibiotics, traditionally require a time-dependent "cold chain" to maximize therapeutic activity. This flawed process results in billions of dollars worth of viable drug loss during shipping and storage, and severely limits distribution to developing nations with limited infrastructure. To address these major limitations, we demonstrate self-standing silk protein biomaterial matrices capable of stabilizing labile vaccines and antibiotics, even at temperatures up to 60 °C over more than 6 months. Initial insight into the mechanistic basis for these findings is provided. Importantly, these findings suggest a transformative approach to the cold chain to revolutionize the way many labile therapeutic drugs are stored and utilized throughout the world.

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    ABSTRACT: Objective: Invasion of illness due to microbes has now becoming a worst situation for health associated professionals. As a fragile product, its storage and handling should be proper as recommended. Background: For the prevention and cure of diseases, vaccine has now become a popular tool biosafety. The main aim of the present study was to find out vaccines’ storage compartment temperature in different private clinics, hospitals, and community pharmacies in Karachi, Pakistan. The desired potency of vaccines is an integral part for vaccination. Result: During present study, visited 803 different clinics, centers, and pharmacies and found refrigerator and/or freezers only 491 clinics, centers, and pharmacies. In these 491, 107 private clinics, 9 governmental health care centers, 56 hospital, and 319 community pharmacies had been selected randomly because they kept vaccines. Only 77.19% were positively responds to our survey. The present study prevailed overall 38.52% and 7.32%, refrigerators and freezers had recommended temperature respectively in clinics, pharmacies, and health care centers. Conclusion: It has been found due to lack of knowledge, insufficient training, importance of cold chain, and above all shortage and/or breakdown of power supply have been played an important role. Based on the present study, it has been forcefully recommended there must be local guidelines or at least national guidelines. It has been tried to enhance the importance of cold chain for vaccines, and endeavor to implement the rules.

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May 23, 2014