Genetically Targetable and Color-Switching Fluorescent Probe

Molecular Biosensor and Imaging Center, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA.
ChemBioChem (Impact Factor: 3.09). 07/2012; 13(11):1564-8. DOI: 10.1002/cbic.201200334
Source: PubMed


Color bind: We have developed a probe TMR-para-MG that switches its fluorescence emission upon binding to a fluorogen-activating protein (FAP). In cells that express FAP, this dye labels target sites in one color and mitochondria in another color, thus it might be a suitable tool for monitoring changes in mitochondrial membrane potential.

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Available from: Dmytro Yushchenko,
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    • "Similarly, MG has been linked to tetramethylrhodamine (TMR) to give TMR-MG (Yushchenko et al., 2012). Like TO1-Cypher5 and dyedrons, TMR-MG was designed for intramolecular energy transfer. "
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