CD47 update: a multi-faceted actor in the tumour microenvironment of potential therapeutic interest.

CNRS, FRE 3481, Matrice Extracellulaire et Dynamique Cellulaire, Université de Reims Champagne-Ardenne, Faculté des Sciences, Reims, France. CNRS, UMR 7213, Laboratoire de Biophotonique et Pharmacologie, Université de Strasbourg, Faculté de Pharmacie Illkirch, France.
British Journal of Pharmacology (Impact Factor: 5.07). 07/2012; DOI: 10.1111/j.1476-5381.2012.02099.x
Source: PubMed

ABSTRACT CD47 is a ubiquitous 50-kDa five-spanning membrane receptor that belongs to the immunoglobulin superfamily. This receptor, also known as IAP (integrin-associated protein), mediates cell-to-cell communication by ligation to transmembrane signal-regulatory proteins SIRPα and SIRPγ and interacts with integrins. CD47 is also implicated in cell-extracellular matrix interactions via ligation with thrombospondins (TSPs). Furthermore, CD47 is involved in many and diverse cellular processes, including apoptosis, proliferation, adhesion and migration. It also plays a key role in many immune and cardiovascular responses. Thus, this multi-faceted receptor might be a central actor in the tumour microenvironment. Solid tumours are composed of not only cancer cells that actively proliferate but also other cell types including immune cells and fibroblasts that make up the tumour microenvironment. Tumour cell proliferation is strongly sustained by continuous sprouting of new vessels, which also represents a gate for metastasis. Moreover, infiltration of inflammatory cells is observed in most neoplasms. Much evidence has accumulated indicating that infiltrating leukocytes promote cancer progression. Given its ubiquitous expression on all the different cell types that compose the tumour microenvironment, targeting CD47 could represent an original therapeutic strategy in the field of oncology. We present a current overview of the biological effects associated with CD47 on cancer cells and stromal cells. © 2012 The Authors. British Journal of Pharmacology © 2012 The British Pharmacological Society.


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Oct 7, 2014