Article

Development of novel herbal cosmetic cream with Curcuma longa extract loaded transfersomes for antiwrinkle effect

African journal of pharmacy and pharmacology (Impact Factor: 0.84). 09/2011; 5:1054-1062.

ABSTRACT Curcuminoids obtained from Curcuma longa have properties like photoprotection, antiaging, anti-wrinkle, moisturizing, antioxidant, astringent, anti-irritant, antimicrobial and anti-inflammatory activities. Our aim was to develop a stable nano-transfersomes loaded cream which could correct the morphological defects and penetrate deeper to the cellular level of dermis to produce anti-wrinkle effect. Soxhlet extraction of C. longa was carried out with two solvents viz. absolute ethanol and 85% ethanol. The transfersomes were prepared by conventional rotary evaporation technique. Various process variables were studied to optimize the formulation including lecithin: surfactant ratio, surfactants (Tween 20, Tween 80) and different solvent extract (95% ethanol and 85% ethanol). 85% ethanolic extract loaded transfersomes (F4) prepared with 4:1 lecithin: surfactant ratio and Tween 20 as the edge activator was found to have maximum entrapment efficiency of 41±1%. Vesicle size obtained was between 200±2 nm range, zeta potential -30±5 mV and polydispersity index between 0.2 to 0.3. After 12 h study curcumin deposition was found to be 45.9%. Transmission electron microscopy of novel cream revealed the presence of spherical double layered transfersome in intact state thus proving the stability of transfersome in cream. Cutometer studies, showed 30 to 50% improvement in relative and absolute skin parameters. The improvements in overall elasticity, biological elasticity, recovery of deformed skin, firmness and reduction in fatigueless can be correlated with anti-wrinkle properties of cream.

6 Followers
 · 
1,314 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The objective of present investigation was to develop rhubarb matrix tablets intended for colon specific delivery system (CoSDS) using two combined approaches of biodegradable microflora-activated system with a pH-sensitive system. Matrix tablets of rhubarb were prepared by wet granulation method using polysaccharide, that is, pectin (10%) alone and in combination with hydrocolloids, that is, hydroxypropyl methylcellulose (HPMC) and hydroxyethylcellulose (HEC) in different concentration of 5, 10, and 15%. Each formulation was characterized in terms of hardness, friability, drug content, disintegration time and in vitro drug release study. On the basis of release profile in the presence of pectinase enzyme after 6 h, formulation containing 10% pectin with 10% HEC was selected as an optimized formulation which was not able to retard the drug release in stomach and upper intestine environment completely. So, it was further coated with eudragit S-100 (ES 100) as a pH sensitive polymer in different coat weight of 3 and 6% w/w. The results obtained reveal that pectin based matrix formulation containing 10% HEC with 6% coat weight of ES 100 exhibited a promising colon targeting performance. There was no significant variation found during stability studies.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Lipid-based innovations have achieved new heights during the last few years as an essential component of drug development. The current challenge of drug delivery is liberation of drug agents at the right time in a safe and reproducible manner to a specific target site. A number of novel drug delivery systems has emerged encompassing various routes of administration, to achieve controlled and targeted drug delivery. Microparticulate lipoidal vesicular system represents a unique technology platform suitable for the oral and systemic administration of a wide variety of molecules with important therapeutic biological activities, including drugs, genes, and vaccine antigens. The success of liposomes as drug carriers has been reflected in a number of liposome-based formulations, which are commercially available or are currently undergoing clinical trials. Also, novel lipid carrier-mediated vesicular systems are originated. This paper has focused on the lipid-based supramolecular vesicular carriers that are used in various drug delivery and drug targeting systems.
    07/2012; 2012:474830. DOI:10.5402/2012/474830