Le traitement de l'état de stress post-traumatique
ABSTRACT L'état de stress post-traumatique (ÉSPT) est un trouble mental commun chez les personnes qui ont été exposées à des évènements traumatiques. Depuis son introduction au sein des systèmes de classification en psychiatrie dans les années 1980, diverses approches psychothérapeutiques ont été mises à l'essai dans le traitement de l'ÉSPT. L'efficacité de ces thérapies dans la réduction des symptômes de stress post-traumatique varie considérablement de l'une à l'autre. Des méta-analyses d'essais cliniques contrôlés à répartition aléatoire ont permis de conclure que les psychothérapies se concentrant sur le traumatisme sont les plus efficaces dans le traitement de l'ÉSPT (Bisson et coll. 2007; Bradley et coll. 2005; Van Etten et Taylor 1998). Les thérapies axées sur les traumatismes comprennent des approches de thérapie cognitivo-comportementale (TCC), particulièrement la thérapie par l'exposition et la thérapie cognitive, ainsi que l' intégration neuro-émotionnelle par les mouvements oculaires (Eye Movement Desensitization and Reprocessing ou EMDR). Une analyse de ces thérapies, de leur fondement théorique, de leurs applications, de leur efficacité et des enjeux entourant leur possibilité d'exécution dans différents contextes est exposée dans le présent article.
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ABSTRACT: The disturbances observed in animals subjected to unpredictable and uncontrollable aversive events resemble post-traumatic stress disorder (PTSD) symptoms and thus may constitute an animal model of this disorder. It is argued that the similarity between animals' symptoms and those of trauma victims may reflect common etiological factors. Relevant experiments in which animals exhibit generalized fear and arousal, discrete fear of a conditioned stimulus (CS), analgesia, and avoidance are reviewed with the view that these manifestations may be analogous to the PTSD symptom clusters of persistent arousal, reexperiencing, numbing, and avoidance, respectively. Finally, animal paradigms are suggested to test the validity of the model and specific hypotheses are derived from the animal literature regarding trauma variables that are predictive of particular PTSD symptom clusters.Psychological Bulletin 10/1992; 112(2):218-38. · 15.58 Impact Factor
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ABSTRACT: We tested whether the effectiveness of imaginal exposure (IE) treatment for posttraumatic stress disorder (PTSD) was enhanced by combining IE with imagery rescripting (IE+IR). It was hypothesized that IE+IR would be more effective than IE by (1) providing more corrective information so that more trauma-related problems can be addressed, and (2) allowing patients to express emotions that they had been inhibiting, such as anger. In a controlled study 71 chronic PTSD patients were randomly assigned to IE or IE+IR. Data of 67 patients were available. Treatment consisted of 10 weekly individual therapy sessions and treatment evaluation was conducted post-treatment and at 1-month follow-up. Results show that when compared with wait-list, treatment reduced severity of PTSD symptoms. More patients dropped out of IE than out of IE+IR before the 8th sessions, 51% vs. 25%, p=.03. Completers and intention-to-treat analyses indicated that both conditions did not differ significantly in reduction of PTSD severity. IE+IR was more effective for anger control, externalization of anger, hostility and guilt, especially at follow-up. Less strong effects were found on shame and internalized anger. Therapists tended to favor IE+IR as it decreased their feelings of helplessness compared to IE. Results suggest that the addition of rescripting to IE makes the treatment more acceptable for both patients and therapists, and leads to better effects on non-fear problems like anger and guilt.Journal of Behavior Therapy and Experimental Psychiatry 01/2008; 38(4):345-70. · 2.23 Impact Factor
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ABSTRACT: Prevailing models of exposure therapy for phobias and anxiety disorders construe level of fear throughout exposure trials as an index of corrective learning. However, the evidence, reviewed herein, indicates that neither the degree by which fear reduces nor the ending fear level predict therapeutic outcome. Developments in the theory and science of fear extinction, and learning and memory, indicate that 'performance during training' is not commensurate with learning at the process level. Inhibitory learning is recognized as being central to extinction and access to secondary inhibitory associations is subject to influences such as context and time, rather than fear during extinction training. Strategies for enhancing inhibitory learning, and its retrieval over time and context, are reviewed along with their clinical implications for exposure therapy and directions for future research.Behaviour Research and Therapy 02/2008; 46(1):5-27. · 3.85 Impact Factor
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Salcioglu E, Başoğlu M (2009) Treatment of Posttraumatic Stress Disorder. In JH Stone, M
Blouin (Eds.). International Encyclopedia of Rehabilitation. Center for International
Rehabilitation Research Information and Exchange (CIRRIE) & L'Institut de Readaptation en
Deficience Physique de Quebec. Available online at http://cirrie.buffalo.edu/encyclopedia/
Treatment of Posttraumatic Stress Disorder
Ebru Salcioglu, PhD
Section of Trauma Studies
Institute of Psychiatry
King’s College London, United Kingdom
Istanbul Center for Behavior Research and Therapy, Turkey
e-mail: Ebru.Salcioglu@iop.kcl.ac.uk ; email@example.com
Metin Basoglu, MD, PhD
Section of Trauma Studies
Institute of Psychiatry
King’s College London, United Kingdom
Istanbul Center for Behavior Research and Therapy, Turkey
Posttraumatic stress disorder (PTSD) is a common mental health problem for people exposed
to traumatic events. Since its introduction into psychiatric classification systems in the 1980s
various psychotherapeutic approaches have been tested for the treatment of PTSD. The
efficacy of these treatments in reducing traumatic stress symptoms varies greatly from one
another. Meta-analyses of randomized controlled clinical trials concluded that trauma focused
psychotherapies are most effective in PTSD (Bisson et al. 2007; Bradley et al. 2005; Van
Etten and Taylor 1998). Trauma-focused treatments include cognitive behavior therapy
(CBT) approaches, particularly exposure and cognitive therapy, and Eye Movement
Desensitization and Reprocessing (EMDR). In this chapter we review these treatments, their
theoretical basis, applications, efficacy, and issues surrounding their practicability in different
Exposure treatment has the largest evidence base and strongest empirical support for efficacy
in the treatment of PTSD. It has been shown to be effective in a wide range of trauma
survivors seeking treatment in clinical settings (see a review in Bradley et al. 2005).
Exposure has its theoretical foundation in learning theory of fear acquisition and extinction.
Learning theory holds that fear is learned through classical conditioning and systematic
exposure to feared stimuli without any adverse consequence results in progressive reduction
in the fear response (i.e. habituation of fear response). The dominant theory of mechanisms of
change in exposure treatment is the emotional processing theory of fear (Foa and Kozak
1986; Foa and McNally 1996). This theory considers fear conditioning within a more
comprehensive cognitive framework and views emotions as represented by information
structures in the memory. Accordingly, fear is viewed as a memory structure that involves
information about feared stimuli, the physiological, behavioral, and cognitive responses they
elicit, and the meaning attributed to the association between feared stimuli and response
elements. Emotional processing involves the modification of memory structure that underlies
fear. Exposure treatment exerts its effect through activation of the ‘fear structure’ and
integration of non-pathological information that is incompatible with it (e.g. disconfirmation
of overestimated probability of harm). The initial fear response and the extent of fear
reduction within and across exposure sessions are indicators of successful emotional
processing that determine the outcome of exposure therapy. Despite its popularity the
emotional processing theory of fear received only partial empirical support. A recent review
(Craske et al. 2008) found weak support for the role of initial fear response and fear reduction
in overall improvement. In some cases improvement occurs despite lack of significant
reductions in fear and anxiety (Craske et al. 2008; Marks and Dar 2000) and in some cases
fear declines despite negative expectations being confirmed during exposure (Marks and Dar
2000). Although exposure works, its mechanisms of action are still to be delineated.
Two forms of exposure are practiced in treatment of PTSD: imaginal exposure to trauma
memories and live exposure to trauma reminders. In imaginal exposure the survivor recounts
anxiety evoking memories about the traumatic event in a systematic, prolonged and repetitive
manner, while in live exposure s/he confronts anxiety evoking reminders of the traumatic
event. Most treatment protocols combine both methods, while a few incorporate only
imaginal exposure (e.g. Bryant et al. 2003; Keane et al. 1989; Tarrier et al. 1999b). The way
imaginal and live exposure is implemented shows variability across treatment programs. For
instance, in the widely used Prolonged Exposure program (Foa et al. 1999a; Foa et al. 2005;
Foa et al. 1991b) live exposure is introduced simultaneously with imaginal exposure and
imaginal exposure is followed by a discussion of emotional responses to trauma memory. In
the well-known Exposure Therapy protocol (Marks et al. 1998; Taylor et al. 2003), on the
other hand, live exposure is introduced midway through the treatment following 5 sessions of
imaginal exposure and emotional responses to trauma memory are not discussed at any stage.
Many treatment programs that are based primarily on these two protocols have also employed
additional interventions such as anxiety management techniques (e.g. relaxation training,
coping skills training, breathing training, thought stopping, and guided self-dialogue) (Cloitre
et al. 2002; Lee et al. 2002), cognitive restructuring (Difede et al. 2007; Fecteau and Nicki
1999; Glynn et al. 1999; Schnurr et al. 2003), supportive counseling (Bryant et al. 2003) and
imagery rescripting (i.e. developing a positive alternative visual representation of oneself
coping more effectively with the trauma during and / or after its occurrence) (Arntz et al.
2007; Grunert et al. 2007). Relatively little research has been conducted to examine the
contribution of these techniques to improvement. While some evidence (Bryant et al. 2003)
suggests that adding cognitive restructuring to exposure enhances treatment effects, other
studies show that cognitive interventions (Foa et al. 2005; Marks et al. 1998; Paunovic and
Öst 2001) or various anxiety management techniques (Foa et al. 1999a) do not confer
additional benefits when used in combination with exposure.
A typical exposure treatment program takes 9-10 weekly sessions to deliver and each
treatment session lasts 60 to 90 minutes. However, the number and duration of sessions vary
greatly in different treatment protocols. In randomized controlled trials of exposure treatment
the number and duration of treatment sessions ranged between 3 and 34 sessions and 50 to
140 minutes, respectively. Although the reasons for this variability are unclear, the inclusion
of additional interventions in the exposure treatment protocols seems to increase the length of
Despite its established efficacy exposure treatment is not widely used in clinical practice. A
survey in the United Kingdom found that a large majority of licensed doctoral level
psychologists do not use exposure therapy to treat patients with PTSD (Becker et al. 2004).
Lack of training was an important factor for this finding, but psychologists’ perception of
likely contraindications of using exposure also posed barriers to its use in clinical practice.
Some authors suggested that high levels of anxiety induced by exposure to trauma memory
and reminders may increase patients’ distress levels, resulting in adverse effects and high
treatment attrition (Kilpatrick and Best 1984; Pitman et al. 1991). The only study (Foa et al.
2002) that examined symptom deterioration in exposure treatment using a reliable definition
of symptom worsening found some increase in PTSD, anxiety and depressive symptoms after
the initiation of imaginal exposure. However, this exacerbation of symptoms was transient
and it was not associated with treatment attrition or outcome. Another study that examined
drop-out rates in 25 treatment studies of PTSD did not find significant differences between
exposure and other trauma focused treatment protocols (Hembree et al. 2003). These findings
did not support reduced tolerability of exposure treatment.
Cognitive therapy is based on the understanding that anxiety occurs due to the selective
processing of information in the environment perceived as signaling threat or danger to the
individual and such cognitive biases can be corrected through conscious reasoning (Beck and
Clark 1997; Beck et al. 1985). In trauma survivors maladaptive appraisals about trauma and
its consequences for one’s life are also thought to play a crucial role in the pathogenesis of
PTSD (Ehlers and Clark 2000; Janoff-Bulman 1992). Therapy is thus designed to restructure
or correct dysfunctional ways of thinking that cause distress, anxiety, or fear. The survivor is
taught to challenge dysfunctional thoughts or beliefs through Socratic reasoning, test their
accuracy through behavioral experiments in situations perceived as threatening or dangerous,
and replace them with alternative ones that better reflect reality. Exposure to trauma
reminders, which is referred to as behavioral experiments, is considered a necessary
component for successful treatment because it allows better processing of threat (Beck and
Clark 1997; Beck et al. 1985). Many cognitive therapy protocols thus involve an exposure
component, but this is limited to only a few sessions and its aim is to teach survivors to
modify their beliefs about the meaning of the traumatic event.
Although all cognitive therapy programs incorporate Socratic reasoning in their protocols
they differ in terms of the beliefs and appraisals they target and in the implementation of the
technique. They also differ in their implementation of exposure in treatment. For example, in
the well-known Cognitive Processing Therapy (Resick and Schnicke 1993) patients are
encouraged to conduct imaginal exposure by writing a detailed account of the trauma, while
they experience their trauma-related emotions, and then by reading the account back to
themselves. In the Cognitive Therapy protocol (Ehlers et al. 2005), on the other hand, a
combination of imaginal and live exposure techniques are used in treatment. Patients are
encouraged to write out a detailed account of the event, relive the event in their imagination,
and revisit the site where trauma occurred. Some other cognitive therapy protocols (Marks et
al. 1998; Tarrier et al. 1999a) do not involve any exposure component.
Randomized controlled trials have established the efficacy of cognitive therapy over waitlist
or minimal attention control groups (Ehlers et al. 2005; Ehlers et al. 2003; Resick et al.
2002). Comparative studies also found cognitive restructuring to be as effective as exposure
(Marks et al. 1998; Resick et al. 2002; Tarrier et al. 1999a). However, the available evidence
is not conclusive regarding the role of cognitive interventions in determining treatment
response. As indicated before, many cognitive therapy programs (Ehlers et al. 2005; Ehlers et
al. 2003; Resick et al. 2002) involved an exposure element which complicates the
understanding of the true effects of cognitive interventions. Although some protocols (Marks
et al. 1998; Tarrier et al. 1999a) have not directly involved exposure, it is possible that they
may have indirectly triggered it. No study has examined whether cognitive therapy has
instigated systematic self-exposure in some survivors between sessions. On the other hand,
even if cognitive change is responsible for treatment outcome, exposure therapy alone may
provide an opportunity to test dysfunctional appraisals about trauma and thereby lead to
cognitive change. There is indeed evidence showing that exposure treatment without
cognitive restructuring produces as much cognitive change as exposure with cognitive
restructuring (Foa and Rauch 2004; Livanou et al. 2002; Paunovic and Öst 2001). Reductions
in negative cognitions were significantly related to reductions in PTSD symptoms in these
studies, suggesting that cognitive change occurs as a response to improvement in PTSD and
not vice versa. These findings support the view that cognitive responses to trauma are
epiphenomena of traumatic stress. Indeed, although survivors with PTSD tend to report more
negative beliefs (Dunmore et al. 1999; Foa et al. 1999b; Steil and Ehlers 2000) or information
processing biases (Foa et al. 1991a; Smith and Bryant 2000; Zoellner et al. 2000), there is no
strong evidence to show that these cause PTSD. Research that employed statistical controls to
examine the role of all possible contributing factors to the disorder (e.g. demographic,
personal history, trauma exposure characteristics etc) has not found a strong association
between beliefs and PTSD (Basoglu et al. 2005a; Salcioglu 2004).
As with exposure treatment the number and duration of treatment sessions show variation
across cognitive therapy programs. In randomized control trials, for example, the treatment
was delivered in 4 to 30 sessions with each session lasting between 60 and 120 minutes. The
fact that different protocols involved different techniques and focused on different cognitive
processes may be responsible for this variability in treatment duration.
Eye Movement Desensitization and Reprocessing (EMDR)
The field of PTSD treatment has witnessed a rapid growth of new treatment protocols, the
most studied of which is undoubtedly EMDR. EMDR is an information processing therapy
during which the patient recounts the traumatic event with its cognitive, affective, and
physiological features while simultaneously focusing visually on bilateral movements of an
external stimulus until the distress evoked by traumatic memory subsides (Shapiro 2001).
EMDR theorists maintain that the eye movements reduce the distress associated with trauma
memories and help with cognitive and emotional reprocessing of the traumatic event. EMDR
has achieved significant treatment effects in randomized controlled trials involving waitlist or
placebo treatment control groups (Bradley et al. 2005). Two methodologically rigorous
studies compared EMDR to exposure treatment. In one of these studies (Taylor et al. 2003),
compared with EMDR, exposure therapy (a) produced significantly larger reductions in
avoidance and re-experiencing symptoms, (b) tended to be faster at reducing avoidance, and
(c) tended to yield a greater proportion of participants who no longer met criteria for PTSD
after treatment. In the other study (Rothbaum et al. 2005) both exposure and EMDR equally
achieved clinically and statistically significant improvements at post-treatment but at the 6-
month follow-up exposure resulted in higher rates of overall improvement than EMDR (78%
vs 35%, respectively).
EMDR combines multiple theoretical perspectives and techniques, most pronouncedly
imaginal exposure and cognitive restructuring. Proponents of EMDR hold that the
requirement of prolonged and uninterrupted exposure for successful fear reduction and
disconfirmation of fear-expectancies in exposure treatment (Foa and Kozak 1986; Marks
1987) is in contrast with the very brief and interrupted nature of imaginal exposure in EMDR
sessions. However, research on the processes of change in exposure treatment has not been
conclusive regarding these requirements (Craske and Mystkowski 2006; Craske et al. 2008).
EMDR proponents also contend that the use of directed eye movements distinguishes this
form of therapy from other cognitive behavioral approaches. However, the role of eye
movements in treatment has not been theoretically clarified and the findings of dismantling
studies (reviewed in a meta-analysis by Davidson and Parker 2001) suggest that the eye
movements are neither necessary nor sufficient to the treatment outcome. These studies call
into question EMDR’s theoretical rationale. It seems that the common sharing of trauma
exposure techniques and emotional reprocessing is principally responsible for treatment gains
in EMDR (American Psychiatric Association 2004).
One important advantage of EMDR is that it is a relatively brief intervention. It achieves its
efficacy in 4 to 6 sessions, lasting 60 to 90 minutes each. It has also been suggested that
because EMDR is less reliant on a verbal account of trauma and provides techniques to
regulate anxiety during imaginal exposure, it is less anxiety provoking and better tolerated
than exposure therapy (American Psychiatric Association 2004; Pitman et al. 1996).
However, no study so far has directly compared the tolerability of these treatments. A study
that examined drop-out rates in 25 treatment studies of PTSD did not find significant
differences between EMDR and exposure (19% vs 20.5%, respectively) (Hembree et al.
Control Focused Behavioral Treatment
The cross-cultural applicability of the interventions reviewed so far is largely unknown as
they were mostly tested in western countries. Their practicability with and efficacy in
survivors of natural disasters and wars are also unknown. As exposure therapy targets
universals of human behavior (fear and anxiety) it would be expected to have promise in
different cultural settings. On the other hand, it is difficult to make predictions about
cognitive interventions, because the cross-cultural validity of maladaptive / faulty thinking
patterns about trauma and its sequelae is not known. Furthermore, the requirements of
keeping homework sheets (Foa et al. 1991b; Resick et al. 2002) and heavy writing tasks
(Resick et al. 2002) involved in exposure and cognitive therapy protocols may complicate
their practicability with survivors with low levels of education that characterize populations
of developing countries. They also pose challenges of use in post-disaster or post-war
settings, where survivors have to deal with day-to-day survival problems. Despite their
relative brevity, exposure and EMDR are not sufficiently brief for easy dissemination after
such mass traumatic events. The high demand for psychiatric care often overwhelms the
clinical resources and high demographic mobility renders treatment attendance difficult for
multiple sessions. The complex procedures involved in conducting imaginal exposure and
cognitive restructuring pose challenges in the training of therapists. They are also not suitable
for dissemination on a self-help basis because they rely on heavy therapist input. Indeed, two
randomized controlled studies failed to demonstrate the efficacy of self-help booklets based
on cognitive behavioral procedures in posttraumatic stress symptoms (Ehlers et al. 2003;
Scholes et al. 2007).
With these considerations in mind we developed a brief and simple version of exposure
treatment after the devastating 1999 earthquakes in Turkey. We modified exposure treatment
by: (a) focusing on only behavioral avoidance (i.e. live exposure to trauma cues); and (b)
shifting the focus of treatment from the habituation to feared stimuli to the enhancement of a
‘sense of control’ over them. The latter modification was based on two considerations:
experimental work with animals show that unpredictable and uncontrollable stressors play an
important role in the development of anxiety and fear responses (Basoglu and Mineka 1992;
Foa et al. 1992) and the evidence from research with trauma survivors (Basoglu et al. 2007a;
Basoglu et al. 2005a; Basoglu et al. 1997; Mineka and Zinbarg 2006; Salcioglu 2004)
suggests that lack of sense of control over traumatic stressors is the critical mediating factor
in PTSD. Helping the person regain control over traumatic stressors might therefore reduce
traumatic stress (Basoglu and Mineka 1992). Some authors also (Craske and Mystkowski
2006; Craske et al. 2008) suggested a shift away from an emphasis on fear reduction during
exposure as an index of learning toward a model of exposure therapy that emphasizes
weakening of avoidance and strengthening tolerance of fear and aversive internal states. The
new Control-Focused Behavioral Treatment (CFBT) thus targeted behavioral avoidance of
trauma reminders and mainly involved therapist-delivered instructions for self-exposure to
feared and avoided situations until the survivor was able to tolerate and felt in control of
anxiety or fear (rather than until ‘fear is reduced’).
CFBT was tested in two open and two randomized clinical trials involving 331 earthquake
survivors with chronic PTSD. In an open trial (Basoglu et al. 2003b) it achieved significant
improvement in 76% of the cases after one session and in 88% of cases after two sessions. In
a randomized controlled study it achieved improvement in 80% of survivors when delivered
in a single session (Basoglu et al. 2005b). Behavioral avoidance was the first symptom to
improve early in treatment (6 weeks), followed by improvement in re-experiencing and
hyperarousal symptoms (Salcioglu et al. 2007). Thus, reduction in avoidance appeared to be
the critical factor that initiated the process of improvement in other symptoms. Further
studies showed that the treatment effect could be enhanced by 20% by an additional session
involving therapist aided exposure to simulated earthquake tremors in an earthquake
simulator (Basoglu et al. 2003a; Basoglu et al. 2007b). Improvement was maintained in the
long-term in all studies, despite further exposure to numerous aftershocks and expectations of
another major earthquake. CFBT also achieved significant improvement when delivered in
the form of a self-help manual after initial contact with a therapist (Basoglu et al. 2009). This
suggested that the important factor in treatment was the effective delivery of the critical
treatment ingredients, rather than the medium of delivery per se. These findings showed that
CFBT shows promise in the treatment of mass trauma survivors in non western settings.
Further studies are needed to confirm these findings in trauma populations living in different
In this chapter we reviewed trauma focused treatment approaches for PTSD. Exposure based
treatments, cognitive therapy, and EMDR are all efficacious treatments for this disorder.
Exposure has several advantages over cognitive therapy and EMDR. Its theoretical
background is more robust and experimentally validated. It also has a larger evidence base,
was tested with a wider range of trauma survivors, and has more promise in cross-cultural
practicability. Despite these advantages exposure therapy is not without problems. About
40% to 50% of patients fail to achieve clinically significant improvement after exposure
therapy. These modest improvement rates could be explained by a strong focus on anxiety
reduction, rather than anxiety tolerance, which may be counterproductive in treatment. Some
authors (Craske and Mystkowski 2006; Craske et al. 2008) suggested a move toward a model
of exposure therapy that emphasizes the weakening of avoidance and strengthening of fear
tolerance. Recent evidence (Basoglu et al. 2003b; Basoglu et al. 2007b; Basoglu et al. 2005b)
from clinical trials with earthquake survivors showed that a behavioral treatment approach
focusing on the enhancement of a sense of control over traumatic stressors and attenuating
avoidance of trauma cues is highly effective in PTSD. Although more controlled studies are
needed to confirm the efficacy of this treatment in other trauma exposed populations, CFBT
appears to be a promising brief treatment for PTSD.
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