Article

A Case of Endocrine Mucin-Producing Sweat Gland Carcinoma Co-existing with Mucinous Carcinoma

The Korean Journal of Pathology (Impact Factor: 0.17). 01/2010; 44441:97-10097.

ABSTRACT An endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare skin tumor that most commonly occurs on the eyelids of elderly women. This tumor is morphologically analo-gous to endocrine ductal carcinoma in situ and solid papillary carcinoma of the breast. We de-scribe one case of a 51-year-old male with an EMPSGC co-existing with mucinous carcinoma of the eyelid. The tumor was composed of dilated ducts with a smooth border and was partial-ly filled with a papillary proliferation. Tumor cells were uniform, small-to-medium in size, and oval-to-polygonal with light eosinophilic cytoplasm. Nuclei were bland with diffusely stippled chromatin and inconspicuous nucleoli. Tumor cells expressed chromogranin, synaptophysin, estrogen and progesterone receptors, cytokeratin 7, and epithelial membrane antigen.An endocrine mucin-producing sweat gland carcinoma (EMPS-GC) is a rare, low-grade sweat gland carcinoma that is morpho-logically analogous to an endocrine ductal carcinoma in situ (E-DCIS)/solid papillary carcinoma of the breast. 1 An EMPSGC is characterized histologically by mucin production, low nuclear grade, and neuroendocrine differentiation. Twenty-three cases of EMPSGCs have been reported in the literature. 1-9 We describe one case of this under-recognized lesion.

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May 23, 2014