Aplicaciones de los cerdos transgénicos en biomedicina y producción animal

01/2010; 106:30-45.

ABSTRACT Resumen Los animales transgénicos han supuesto un gran avance en el campo de la ciencia y de la salud. Los avances tecnológicos en este campo han permitido desarrollar una amplia variedad de cerdos trans-génicos con diversos objetivos y aplicaciones. En este documento hemos descrito y analizado las diver-sas aplicaciones que los cerdos transgénicos han tenido y tienen en el ámbito biomédico y en el agro-pecuario. Entre estas aplicaciones en el campo de la salud destacamos los modelos de enfermedad humana, la generación de productos biofarmaceuticos y el transplante de órganos de cerdos modifi-cados a humanos (xenotransplante). Por otra parte, la resistencia a las enfermedades, la mejora de los indices productivos y la reducción del efecto contaminante de la actividad ganadera son las principa-les aplicaciones de los cerdos transgénicos en producción animal. El uso de cerdos transgenicos está más desarrollado en el campo de la biomedicina que en el agropecuario, fundamentalmente por las limitaciones que existen actualmente en el consumo de productos alimentarios derivados de los orga-nismos modificados genéticamente (OMG's). Palabras clave: salud, modelos enfermedad, biofármacos, xenotransplantes, mejora productiva, con-taminación. Summary Applications of transgenic pigs in biomedicine and animal production Transgenic animals have been a great improvement for science and health. The lastest technological developments have lead to the generation of a broad variety of transgenic pigs with diverse aims and applications. In this manuscript, we describe and analyze the usage and applications of the transgenic pigs in biomedicine and agriculture. The applications of transgenic pigs in biomedicine included models for human diseases, production of bio-pharmacological substances and xenotransplantation. The agriculture applications of transgenic pigs are disease resistance, increases in the production and quality of animal products and pollution reduction. The use of transgenic pigs is higher in biomedici-ne than in agriculture. This is due to the severe restriction of consumption of food products derived from genetic modified organisms (GMO's).

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Available from: Joaquin Gadea, Aug 28, 2015
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