Article

Immunomodulation par les nutriments

Nutrition Clinique et Métabolisme 06/2006; 20(2). DOI: 10.1016/j.nupar.2006.04.002

ABSTRACT Disponible sur internet le 26 mai 2006 Résumé De nombreux nutriments sont reconnus pour leur capacité à moduler les fonctions immunitaires, en particulier en situation inflammatoire. De nombreux travaux, tant expérimentaux que cliniques, ont pu ainsi démontrer le rôle de certains acides aminés (glutamine, arginine), des lipides (acides gras poly-insaturés des séries n-3 et n-6), des vitamines antioxydantes et des oligoéléments. De ces observations est né le concept des mélanges immunomodulateurs enrichis en arginine, glutamine, acides gras poly-insaturés et/ou micronutriments. Le but de ces mélanges est de corriger les anomalies des réponses immunitaires et inflammatoires observées chez les patients agressés. Si ces mélanges sont efficaces en périopératoire, leur utilisation chez les patients de réanimation ou de soins intensifs est toujours controversée. Ainsi, de nombreux travaux sont encore nécessaires afin d'optimiser l'utilisation de tels mélanges. Abstract Many studies have well demonstrated that selected nutrients may have pharmacological effects on immunity in catabolic state. Hence, experi-mental and clinical trials had characterized the properties of selected amino acids (glutamine, arginine), lipids (ω 3 and 6 polyunsaturated fatty acids), vitamins and antioxidants. Following this concept, specific diets have been formulated with some of these nutrients in order to improve immune responsiveness and clinical outcome of patients. These diets already demonstrated their efficiency when they were given to patients in peri-operative situations. However, their use in ICU patients is still controversial. Further studies are required to develop an optimal IED for ICU patients.

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May 29, 2014