The effect of β-glucan on prolactin secretion in GH3/B6 cells

© Shiraz University
Iranian Journal of Science & Technology, Transaction A 06/2007; 31(3).


It is well known that several plant extracts have a lactogenic effect. This response may be induced through the stimulation of prolactin release from lactotrope cells. A partial purification of the active compound indicated that it is rich in pectin and β-glucan. These materials stimulate secretion of prolactin from hypophyseal fragments. In the present study, the effect of β-Glucan on the secretion of prolactin from GH3/B6 pituitary tumor cells has been investigated. These cells are good tools for studying the direct effect of β-glucan on prolactin secretion. The different concentrations of β-glucan (50, 100 and 200 µg/ml) increased secretion of prolactin within 24 hours of incubation in GH3/B6 media. Moreover, the secretion of prolactin was significantly elicited at 100 and 200 µg/ml of β-glucan incubation after 48 hours. These results suggest that β-glucan can affect the synthesis and/or release of prolactin, a hormone that plays many important physiological roles from GH3/B6 pituitary tumor cells.

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