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Available from: Louis Bont, Oct 05, 2015
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    ABSTRACT: The occurrence of RSV infection and disease was examined with respect to patient age, immunologic status, race and sex. The peak incidence of RSV bronchiolitis and pneumonia was observed at 2 mth of age. Thereafter the incidence of these diseases decreased with increasing age, more rapidly for bronchiolitis than for pneumonia. Each of 75 patients who had RSV bronchiolitis or pneumonia during the first 3 mth of life possessed neutralizing antibody in his serum during the acute phase of illness. In most instances the level of this antibody, presumably of maternal origin, was moderately high. In contrast, 15 of 57 infants who developed RSV bronchiolitis at 4-7 mth of age lacked detectable antibody in their acute phase serum. This finding casts some doubt upon the essential role of serum antibody in RSV bronchiolitis. The serum CF antibody response to RSV was impaired in infants 1-3 mth of age. The level of acute phase serum neutralizing antibody was inversely related to the height of the serum complement fixation antibody response during convalescence, suggesting that maternally derived antibody may have suppressed the immunologic response of some infants. The clinical consequences of RSV infection in infancy did not appear to be influenced by race. The same proportion of males and females with respiratory tract disease yielded RSV; however, significantly more boys were admitted to the hospital for RSV pneumonia, bronchiolitis, croup and pharyngitis bronchitis.
    American Journal of Epidemiology 11/1973; 98(4):289-300. · 5.23 Impact Factor
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    ABSTRACT: Respiratory syncytial virus is the most important cause of serious lower respiratory tract infection in children. For children followed up from birth in the Houston Family Study, the infection rate was 68.8/100 children less than 12 months of age and 82.6/100 during the second year of life. Virtually all children had been infected at least once by 24 months of age, and about one half had experienced two infections. Although lower respiratory tract disease (LRD) was common (22.4/100 during year 1 and 13.0/100 during year 2), most children had only one LRD illness. The risk of reinfection was inversely related to the level of neutralizing antibodies in the serum. Reinfection illnesses were generally mild, and risk of reinfection decreased to only 33.3/100 during year 4. Studies of children with LRD and surveys of hospitalizations provide the basis for an estimate of the number of children hospitalized each year during the respiratory syncytial virus epidemics. Almost 100,000 children in the United States experience an illness of sufficient severity to require hospitalization.
    American journal of diseases of children (1960) 07/1986; 140(6):543-6.
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    ABSTRACT: Hospitalization rates for respiratory syncytial virus (RSV) infection range from 1 to 20/1000 infants. To determine the rate and severity of RSV infections requiring hospitalization for infants in the Yukon-Kuskokwim (YK) Delta of Alaska, a 3-year prospective surveillance study was conducted. The annual rate of RSV hospitalization for YK Delta infants <1 year of age was 53-249/1000. RSV infection was the most frequent cause of infant hospitalization. RSV disease severity did not differ among non-high-risk infants in the YK Delta and at Johns Hopkins Hospital (JHH). On average, 1/125 infants born in the YK Delta required mechanical ventilation for RSV infection. During the peak season, approximately $1034/child <3 years of age was spent on RSV hospitalization in the YK Delta. In YK Delta infants </=6 months old, RSV microneutralizing antibody titers <1200 were associated with severe disease (odds ratio=6.2, P=.03). In the YK Delta and at JHH, newborns may be at greater risk for severe RSV illness than previously thought.
    The Journal of Infectious Diseases 08/1999; 180(1):41-9. DOI:10.1086/314841 · 6.00 Impact Factor
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