Elementos para la evaluación eficaz de productos naturales con posibles efectos antihipertensivos
ABSTRACT Desde el contexto de la farmacología experimental, en este ensayo se discuten algunos criterios que pueden ser útiles para estimar el potencial de productos naturales con posible actividad farmacológica para el tratamiento de la hipertensión, una de las enfermedades de mayor impacto epidemiológico en Colombia y en el mundo. Se acude para ello al análisis de algunas pruebas farmacológicas accesibles en nuestro medio: modelos de hipertensión arterial en la rata de laboratorio, pruebas in vitro e in vivo, y análisis microscópicos, que implementados con los protocolos adecuados y cotejadas en conjunto, pueden arrojar información valiosa a la hora de considerar las perspectivas de un producto natural en el campo de la hipertensión arterial. Palabras clave: evaluación de medicamentos, productos biológicos, hipertensión, resistencia vascular, ratas, modelos cardiovasculares. Elements for the effective evaluation of natural products with possible antihypertensive effects Within the context of experimental pharmacology, some criteria are discussed for estimating the potential of natural products with possible pharmacological activity for the treatment of hypertension. This disorder has great epidemiological impact in Colombia as well as elsewhere. Discovery of these products can be accomplished by use of accessible pharmacological tests such as the following: developing models of arterial hypertension in the laboratory rat, in vitro tests, in vivo tests and microscopic analysis. Suitable protocols associated with these techniques can capture valuable information about possible effects on hypertension during the evaluation phase of a natural product.
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ABSTRACT: Diabetes mellitus and hypertension (high blood pressure) are the most common diseases with high risk affecting most of the worldwide adult population in both sexes. In Mexico, cardiovascular diseases are the first cause of morbidity and mortality. Diabetes mellitus is the first cause of death in women and ischemic heart disease becomes the leading cause of mortality in men; high blood pressure is one of the major risk factors for coronary artery disease and stroke, is currently among the ten leading causes of death worldwide. Generally, for the therapeutic management of both diseases is using multiple drugs with different chemical structures and different mechanisms of action, which aim to normalize blood glucose and blood pressure levels. These are managed for a long time, which often represents a high economic cost. On the other hand, some patients have no adherence to treatment as this one, is ineffective, the adverse effects are situations that require change or discontinue medication immediately. With these remarks it is important the developments of new antidiabetic or antihypertensive agents, the medicinal plants are an option. Scientific interest aimed at the search phytotherapeutic drugs for the treatment of these diseases has led the conduct of research that validates the use of medicinal plants, or they have found new agents with antidiabetic and antihypertensive properties. In Mexico, has been reported at educational institutions and research, a number of plants widely used in Mexican folk medicine, with high potential to be used in the treatment of diabetes mellitus and hypertension.Pharmacologyonline 08/2013; 2:15-23. · 0.16 Impact Factor
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ABSTRACT: The cardiovascular disorder of hypertension is one of the main non-communicable diseases worldwide, and is responsible for over 80% of the deaths in low- and middle-income countries. Justicia spicigera (muicle) is a plant used in Mexican traditional medicine for the treatment of various disorders, including hypertension. The principle aim of this work was to evaluate the effects on blood pressure of different extracts taken from the aerial parts of the muicle plant Justicia spicigera (Acanthaceae). To the best of our knowledge there are no such previous reports. For the purpose of this study, the extracts were applied in hypertensive L-NAME Wistar rats. The results show that hexane and methanol extracts did not lower blood pressure and the aqueous extract only decreased the diastolic blood pressure (from 163/148 ± 6.65/6.64 mmHg to 156/128 ± 11.8/4.51 mmHg) in the hypertensive rats, but not in the normotensive animals. However, the chloroform extract lowered the arterial blood pressure (180/164 ± 1.7/3.2 mmHg) to values similar to those of the normotensive rats (149/133 ± 4.0/3.7 mmHg). The extracts had no effect on the control animals and the vehicles did not modify arterial blood pressure in any of the animals. Finally, the chloroform extract of aerial parts of J. spicigera was further analyzed by high performance liquid chromatography (HPLC) to identify and quantify major bioactive flavonoid compounds profile. As revealed by the results, the chloroform extract yielded three major flavonoid compounds, identified as hesperidin, naringenin and kaempferol, metabolites that could be responsible of antihypertensive effects of J. spicigera.PharmocologyOnline. 08/2013; 2:120-127.