Onion (Allium cepa) extract attenuates brain edema
ABSTRACT OBJECTIVE: This study investigated the potential beneficial effects of onion extract on brain ischemia-induced edema and blood-brain barrier (BBB) dysfunction. The possible underlying mechanisms are investigated, especially those linked to the antioxidant effects of the onion extract. METHODS: Brain ischemia was induced by middle cerebral artery occlusion (MCAO) for 2 h followed by reperfusion in mice. Mice were treated intravenously with onion extract 30 min before MCAO. Brain edema and BBB hyperpermeability were evaluated by the measurement of the brain water content and Evans blue extravasation, respectively. The disruption of tight junction proteins was examined by immunohistochemical staining. The level of malondialdehyde was determined using the thiobarbituric acid method. The activities of glutathione peroxidase and catalase were determined by spectrophotometric assay. RESULTS: Brain water content in the ischemic hemisphere was significantly reduced by treatment with onion extract. Onion extract also had a significant effect on both the decrease in Evans blue extravasation and the inhibition of zonula occludens-1 and occludin disruption caused by brain ischemia. In addition, onion extract significantly prevented brain ischemia-induced reduction in catalase and glutathione peroxidase activities and elevation of malondialdehyde level in the brain tissue. CONCLUSION: The results from this study demonstrate that onion extract prevents brain edema, BBB hyperpermeability, and tight junction proteins disruption, possibly through its antioxidant effects in the mouse MCAO model. This study suggests that onion extract may be a beneficial nutrient for the prevention of BBB function during brain ischemia.
Article: Oignon — Allium cepa, bulbe[Show abstract] [Hide abstract]
ABSTRACT: L’oignon est particulièrement indiqué pour le patient pléthorique bouffi ou oedémateux, dyspeptique, diabétique, prostatique. Il exerce une activité anti-inflammatoire, antiallergique, et contribue à prévenir certains cancers. Son activité antiseptique et anticatarrhale le rend utile en cas de rhume. Son activité antiagrégante plaquettaire semble insuffisante in vivo. Il est aussi neuroprotecteur et freine l’activité ostéoclastique. On conseille de manger trois à six oignons par jour (30 à 50 g), de préférence crus.Phytotherapie 02/2012; 11(1). DOI:10.1007/s10298-012-0747-5
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ABSTRACT: Onion has several well-known biological functionalities, including antioxidant effects, and contains quercetin (3,3',4,5,7-pentahydroxyflavone), a powerful antioxidant. In the present study, we observed neuroprotective effects of onion extract (OE) and its major component, quercetin, on ischemic damage in the gerbil hippocampus, which is related to memory function. Repeated treatment with 100 mg/kg OE and 20 mg/kg quercetin for 15 days before ischemic surgery protected pyramidal neurons of the hippocampal CA1 region from ischemic damage. In the OE-treated ischemic group, gliosis (activation of astrocytes and microglia) was attenuated in the CA1 4 days after ischemia/reperfusion. In addition, treatment with OE and quercetin decreased protein levels of 4-hydroxy-2-nonenal (a marker for lipid peroxidation) in the ischemic CA1. We suggest that repeated administration of OE and quercetin can protect against neuronal damage from transient cerebral ischemia.Journal of medicinal food 10/2009; 12(5):990-5. DOI:10.1089/jmf.2008.1400 · 1.70 Impact Factor
- Nutrition 08/2012; 28(11-12):1192-3. DOI:10.1016/j.nut.2012.03.015 · 3.05 Impact Factor