Validation of the Face Name Associative Memory Exam in cognitively normal older individuals.

Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Journal of Clinical and Experimental Neuropsychology (Impact Factor: 2.16). 07/2012; 34(6):580-7. DOI: 10.1080/13803395.2012.666230
Source: PubMed

ABSTRACT The recently developed Face Name Associative Memory Exam (FNAME), a challenging paired associative learning task, shows promise in detecting the subtle cognitive changes characteristic of preclinical Alzheimer's disease. In this study, we evaluated the validity and reliability of the FNAME in 210 cognitively normal older individuals (58-90 years of age). Construct validity of the measure was assessed by principal components analysis, which revealed two independent factors. Correlations between the FNAME subtests and another episodic memory test were significant. The results indicated strong test-retest reliability in a subsample (n = 41). Normative data stratified by age were also generated.

  • Source
    • "Using the factor weights from this prior analysis, a factor score for memory was derived for each participant. The tests included in this factor score are the following: number of errors produced on the Self-Ordered Pointing task (95% of older participants completed; adapted from Petrides and Milner, 1982; Shimamura and Jurica, 1994), cued recall names, and cued recall occupations scores from the Face-Name Associative Memory Exam (99% of older participants completed; Amariglio et al., 2012; Rentz et al., 2011), delayed recall from the Six- Trial Selective Reminding Test (99% of older participants completed; Masur et al.,1990), and Free Recall, list two, from the Memory Capacity Test (99% of older participants completed; Rentz et al., 2010). Missing data on individual tests were imputed using a linear regression approach. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Advanced aging negatively impacts memory performance. Brain aging has been associated with shrinkage in medial temporal lobe structures essential for memory-including hippocampus and entorhinal cortex-and with deficits in default-mode network connectivity. Yet, whether and how these imaging markers are relevant to age-related memory deficits remains a topic of debate. Using a sample of 182 older (age 74.6 ± 6.2 years) and 66 young (age 22.2 ± 3.6 years) participants, this study examined relationships among memory performance, hippocampus volume, entorhinal cortex thickness, and default-mode network connectivity across aging. All imaging markers and memory were significantly different between young and older groups. Each imaging marker significantly mediated the relationship between age and memory performance and collectively accounted for most of the variance in age-related memory performance. Within older participants, default-mode connectivity and hippocampus volume were independently associated with memory. Structural equation modeling of cross-sectional data within older participants suggest that entorhinal thinning may occur before reduced default-mode connectivity and hippocampal volume loss, which in turn lead to deficits in memory performance.
    Neurobiology of Aging 07/2014; 36(1). DOI:10.1016/j.neurobiolaging.2014.06.028 · 4.85 Impact Factor
  • Source
    • "Previous work in a larger sample of older adults (n = 210) showed two underlying factors comprising the original FNAME—face–name recall (IRN, CRN, CRN30) and face–occupation recall (IRO, CRO, CRO30)—explaining 76% and 17% of the variance , respectively, in a Principal Components Analysis (Amariglio et al., 2012). Given these findings, we created equivalent summary scales for FNAME-12: FN-N items (IRN, CRN, CRN30) and FN-O items (IRO, CRO, CRO30) as well as a Total Score (FN-N + FN-O). "
    [Show abstract] [Hide abstract]
    ABSTRACT: Neuropsychologists are developing more challenging and specific tests to detect early and subtle changes in cognition related to preclinical Alzheimer's disease (AD). The 16-item Face-Name Associative Memory Exam (FNAME-16) is a challenging paired associative memory test able to detect subtle memory changes associated with biomarker evidence of preclinical AD. However, as individuals progress along the AD trajectory, measures that are sensitive at the preclinical stage may become too challenging by the stage of Mild Cognitive Impairment (MCI). Our goal was to develop a modified version of the face-name and face-occupation paired associative memory task (FNAME-12) with fewer stimuli and additional learning trials suitable for use in MCI. We administered the FNAME-12A, an alternate version FNAME 12B, the original FNAME-16, and a series of other neuropsychological measures to 65 clinically normal (CN) older adults (aged 65 to 85) and a subsample characterized by MCI (n = 18). The FNAME-12 exhibited psychometric equivalence with the FNAME-16 (r = .77, p < .001) and was correlated with other measures of episodic and semantic memory. The alternate form, FNAME-12B, was highly correlated with FNAME-12A (r = .76, p < .001). Mean performance on the FNAME 12A, stratified by education, was generated. The task could be completed by our MCI group yet remained challenging in the CN group, providing evidence for its utility along the AD trajectory.
    The Clinical Neuropsychologist 05/2014; 28(5):1-15. DOI:10.1080/13854046.2014.911351 · 1.58 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Amyloid burden and white matter hyperintensities (WMH) are two common markers of neurodegeneration present in advanced aging. Each represents a potential early indicator of an age-related neurological disorder that impacts cognition. The presence of amyloid is observed in a substantial subset of cognitively normal older adults, but the literature remains equivocal regarding whether amyloid in nondemented populations is deleterious to cognition. Similarly, WMH are detected in many nondemented older adults and there is a body of evidence indicating that WMH are associated with decreased executive function and other cognitive domains. The current study investigated amyloid burden and WMH in clinically normal older adult humans aged 65-86 (N = 168) and examined each biomarker's relation with cognitive domains of episodic memory, executive function, and speed of processing. Factors for each domain were derived from a neuropsychological battery on a theoretical basis without reference to the relation between cognition and the biomarkers. Amyloid burden and WMH were not correlated with one another. Age was associated with lower performance in all cognitive domains, while higher estimated verbal intelligence was associated with higher performance in all domains. Hypothesis-driven tests revealed that amyloid burden and WMH had distinct cognitive profiles, with amyloid burden having a specific influence on episodic memory and WMH primarily associated with executive function but having broad (but lesser) effects on the other domains. These findings suggest that even before clinical impairment, amyloid burden and WMH likely represent neuropathological cascades with distinct etiologies and dissociable influences on cognition.
    The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 11/2012; 32(46):16233-16242. DOI:10.1523/JNEUROSCI.2462-12.2012 · 6.75 Impact Factor
Show more