The utility of ATF3 in distinguishing cutaneous squamous cell carcinoma among other cutaneous epithelial neoplasms

Department of Pathology, Section of Dermatopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Journal of Cutaneous Pathology (Impact Factor: 1.58). 07/2012; 39(8):762-8. DOI: 10.1111/j.1600-0560.2012.01938.x
Source: PubMed


The histopathologic distinction between benign and malignant cutaneous keratinocytic proliferations can pose a difficult diagnostic challenge - often with important clinical implications. Activating transcription factor 3 (ATF3) has emerged as a potential biomarker which may aid in the segregation of these lesions, and we hypothesize that ATF3 expression may be a specific marker of cutaneous squamous cell carcinoma (SCC). Using immunohistochemistry, we characterized ATF3 expression in a series of 126 cutaneous epithelial proliferations, including SCC (n = 27), basal cell carcinomas (BCC, n = 59), seborrheic keratoses with atypia (SK, n = 16), hyperplastic actinic keratoses (AK, n = 12) and prurigo nodularis cases (PN, n = 12). We showed strong, nuclear and/or nucleolar expression of ATF3 in a statistically significant number of cases of SCC compared to BCC, SK and PN. We conclude that ATF3 expression is a surrogate of malignancy (or pre-malignancy) in keratinocytic epithelial proliferations and thus helps distinguish SCC from other cutaneous epithelial neoplasms.

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    • "addressed in several cell lines that ATF3 might be involved in homeostasis, wound healing, cell adhesion, cancer cell invasion, apoptosis and signaling pathways (Chen et al., 1996; Wolfgang et al., 1997; Ishiguro and Nagawa, 2000; Ishiguro et al., 2000; Wolfgang et al., 2000; Allen-Jennings et al., 2001; Gold et al., 2012; Jang et al., 2012; Rose et al., 2012). Over-expression of ATF3 protein moderately suppresses cell growth through slowing down progression from G1/S transition in Hela cells (Fan et al., 2002). "
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