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CRGD-functionalized mPEG-PLGA-PLL nanoparticles for imaging and therapy of breast cancer

Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, No.25, Lane 2200, Xietu Road, Shanghai 200032, PR China.
Biomaterials (Impact Factor: 8.31). 07/2012; 33(28):6739-47. DOI: 10.1016/j.biomaterials.2012.06.008
Source: PubMed

ABSTRACT Cyclic peptide (arginine-glycine-aspartic-glutamic-valine acid, cRGD)-modified monomethoxy (polyethylene glycol)-poly (D,L-lactide-co-glycolide)-poly (L-lysine) nanoparticles (mPEG-PLGA-PLL-cRGD NPs) with antitumor drug Mitoxantrone (DHAQ) or fluorescence agent Rhodamine B (Rb) encapsulated in their interior were prepared. The remarkable features of the mPEG-PLGA-PLL-cRGD NPs are the effective improvement for the cytotoxicity and uptake of the cell in vitro, and the significant enhancement of delivery ability for DHAQ or Rb in vivo. As a consequence, an excellent therapeutic efficiency for cancer is obtained, demonstrating the mPEG-PLGA-PLL-cRGD NPs play a key role in enhancing cancer therapeutic efficiency.

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