Prevalence of dyslipidemia and associated factors in the Yi farmers and migrants of Southwestern China.
ABSTRACT There are scant data on serum lipid profile in the Yi people in China. The Yi farmers and migrants provide an unusual opportunity to estimate effects of environmental factors on serum lipid levels. We conducted a cross-sectional study in the Yi people to estimate prevalence of dyslipidemia and associated factors. It was found that prevalence of high total cholesterol (TC), triglyceride (TG), low-density lipoprotein-cholesterol (LDL-C), abnormal ratio of TC/HDL-C and low high-density lipoprotein-cholesterol (HDL-C) were 1.82%, 5.07%, 1.56%, 9.30% and 39.47%, respectively in the Yi farmers. And those in the Yi migrants were 4.81%, 22.21%, 3.24%, 26.56% and 40.53%. Prevalence of dyslipidemia increased with time period in the Yi farmers after their emigrating to urban areas for less than 25 years, except high TC. It was also found that prevalence of dyslipidemia of the Yi migrants increased with time period before their emigration, including hypertriglyceridemia, low HDL-C and high ratio of TC/HDL-C. Their body mass index (BMI), history of type 2 diabetes mellitus (T2DM), gender, ever alcohol drinking and physical activity all were associated with dyslipidemia, but no factors associated with high LDL-C was found. In conclusion, all these results suggest that the Yi migrants have a higher prevalence of dyslipidemia than the Yi farmers do, which possibly can attribute to their urbanized lifestyles.
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ABSTRACT: Dyslipidemia is a key independent modifiable risk factor for Cardiovascular Disease, which is a leading contributor to morbidity and mortality in most developed and developing countries. This study was designed to investigate the current epidemiological features of dyslipidemia among adults in rural China. Between January 2013 and August 2013, we conducted a cross-sectional study involving 11,956 subjects with age >=35 years in a general Chinese population. Permanent residents of the population were invited to participate in the study and the response rate was at 85.3%. Dyslipidemia was identified based on serum lipids levels following the standards proposed by the National Cholesterol Education Program Adult Treatment Panel III. Multivariate logistic regression analysis was used to evaluate the associated risk factors for dyslipidemia. Within the study population, 16.4% had high TC, 13.8% had low HDL-C, 7.6% had high LDL-C, and 17.3% had high TG concentrations. Prevalence of lipid abnormality (including borderline dyslipidemia and dyslipidemia) was 47.8%, 13.8%, 25.7% and 30.7% for TC, HDL-C, LDL-C and TG, respectively. Detailed analysis indicated that 36.9% of this population had at least one type of dyslipidemia and 64.4% had at least one type of abnormal lipid concentration. Thus, this study observed an alarmingly higher prevalence of lipid abnormality, in a relatively large population, compared to previous studies. Further, we determined that not all of the risk factors studied, including age, gender, hypertension, diabetes mellitus, obesity, smoking, drinking, education level, marital status, and family income, influenced dyslipidemia to the same extent. Our present study, in a population of 11,956 adults in Liaoning Providence, demonstrated a very high prevalence of dyslipidemia, which represented an alarming rise since the publication of our previous study and other similar studies around the world, which report lower levels. We also examined various risk factors for dyslipidemia, many of which are modifiable risk factors for Cardiovascular Disease (CVD), to provide a comprehensive view that will help in designing strategies to slow the rapid spread and promote effective measures to treat dyslipidemia. Our ultimate goal is to prevent the increasing prevalence of lipid abnormality and reduce the burden of CVD in rural China.Lipids in Health and Disease 12/2014; 13(1):189. DOI:10.1186/1476-511X-13-189 · 2.31 Impact Factor
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ABSTRACT: We aimed to establish the reference intervals for serum lipids in coastal residents of the Chinese male population. A total of 1436 subjects, aged between 19 and 86 years, were selected from the Fangchenggang Area for Male Health and Examination Survey (FAMHES). Reference intervals of serum lipids were measured by enzymatic endpoint colorimetry and information was obtained using a standard questionnaire. The total nonparametric reference intervals for TC < 5.95 mmol/L (229.73 mg/dL), TG < 1.80 mmol/L (158.82 mg/dL), HDL-C > 1.90 mmol/L (73.08 mg/dL), and LDL-C < 3.37 mmol/L (130 mg/dL). High serum lipid levels were correlated with older age, higher body mass index (BMI), and more smoking, but not with alcohol consumption. The established reference intervals of serum lipids for coastal Chinese male residents would be helpful for assessing risk of cardiovascular disease. We recommend establishing population-based reference intervals for serum lipids in clinical laboratories.Clinical laboratory 01/2013; 59(11-12):1289-95. DOI:10.7754/Clin.Lab.2013.121124 · 1.08 Impact Factor