There are scant data on serum lipid profile in the Yi people in China. The Yi farmers and migrants provide an unusual opportunity to estimate effects of environmental factors on serum lipid levels. We conducted a cross-sectional study in the Yi people to estimate prevalence of dyslipidemia and associated factors. It was found that prevalence of high total cholesterol (TC), triglyceride (TG), low-density lipoprotein-cholesterol (LDL-C), abnormal ratio of TC/HDL-C and low high-density lipoprotein-cholesterol (HDL-C) were 1.82%, 5.07%, 1.56%, 9.30% and 39.47%, respectively in the Yi farmers. And those in the Yi migrants were 4.81%, 22.21%, 3.24%, 26.56% and 40.53%. Prevalence of dyslipidemia increased with time period in the Yi farmers after their emigrating to urban areas for less than 25 years, except high TC. It was also found that prevalence of dyslipidemia of the Yi migrants increased with time period before their emigration, including hypertriglyceridemia, low HDL-C and high ratio of TC/HDL-C. Their body mass index (BMI), history of type 2 diabetes mellitus (T2DM), gender, ever alcohol drinking and physical activity all were associated with dyslipidemia, but no factors associated with high LDL-C was found. In conclusion, all these results suggest that the Yi migrants have a higher prevalence of dyslipidemia than the Yi farmers do, which possibly can attribute to their urbanized lifestyles.
"The triglyceride and LDLC increased in obese compared to non-obese and the decrease of HDLC was significant in obese. These findings are in agreement with those of previous studies (Kanaya et al., 2003; Cai et al., 2012; Wang et al., 2012;Sun et al., 2014). "
[Show abstract][Hide abstract] ABSTRACT: The study was undertaken to evaluate the interest of cholesterol subclasses in the management of hypertensive patients recruited at University Hospital Yalgado Ouedraogo of Ouagadougou (Burkina Faso, West Africa). The distribution of hypertensive was reported as 45 (35.4%) without complications, 42 (33%) with cardiovascular complications and 40 (31.4%) with diabetes. Any difference in lipids profile was observed when balanced hypertensive was compared to non-balanced hypertensive. The total cholesterol (TC), high density lipoprotein cholesterol (HDLC) and HDL3 cholesterol (HDL3C) were significantly higher in hypertensive compared to the control group (p<0.001). Significant decrease of TC and HDLC levels was observed in women within hypertensive group (p<0.05). The increase in triglyceride (TG) and low density lipoprotein cholesterol (LDLC) was significant in obese compared to non-obese. The HDLC level was higher (p<0.01) in treated hypertensive compared to untreated, particularly females. The HDLC increased significantly in treated hypertensive without complications (p<0.01). The TC and LDLC levels were higher in treated hypertensive with diabetes (p<0.05). The HDL2 cholesterol (HDL2C) was significantly lower in treated hypertensive with diabetes (p<0.05), and particularly in obese compared to non-obese. A significant decrease of HDL2C was observed in female stage 3 hypertensive (p<0.05). The HDL2C might be a better predictor of cardiovascular risks in hypertensive if the relationship between its decrease with severity of hypertension is confirmed by further studies.
[Show abstract][Hide abstract] ABSTRACT: We aimed to establish the reference intervals for serum lipids in coastal residents of the Chinese male population.
A total of 1436 subjects, aged between 19 and 86 years, were selected from the Fangchenggang Area for Male Health and Examination Survey (FAMHES). Reference intervals of serum lipids were measured by enzymatic endpoint colorimetry and information was obtained using a standard questionnaire.
The total nonparametric reference intervals for TC < 5.95 mmol/L (229.73 mg/dL), TG < 1.80 mmol/L (158.82 mg/dL), HDL-C > 1.90 mmol/L (73.08 mg/dL), and LDL-C < 3.37 mmol/L (130 mg/dL). High serum lipid levels were correlated with older age, higher body mass index (BMI), and more smoking, but not with alcohol consumption.
The established reference intervals of serum lipids for coastal Chinese male residents would be helpful for assessing risk of cardiovascular disease. We recommend establishing population-based reference intervals for serum lipids in clinical laboratories.
[Show abstract][Hide abstract] ABSTRACT: Dyslipidemia is a key independent modifiable risk factor for Cardiovascular Disease, which is a leading contributor to morbidity and mortality in most developed and developing countries. This study was designed to investigate the current epidemiological features of dyslipidemia among adults in rural China.
Between January 2013 and August 2013, we conducted a cross-sectional study involving 11,956 subjects with age >=35 years in a general Chinese population. Permanent residents of the population were invited to participate in the study and the response rate was at 85.3%. Dyslipidemia was identified based on serum lipids levels following the standards proposed by the National Cholesterol Education Program Adult Treatment Panel III. Multivariate logistic regression analysis was used to evaluate the associated risk factors for dyslipidemia.
Within the study population, 16.4% had high TC, 13.8% had low HDL-C, 7.6% had high LDL-C, and 17.3% had high TG concentrations. Prevalence of lipid abnormality (including borderline dyslipidemia and dyslipidemia) was 47.8%, 13.8%, 25.7% and 30.7% for TC, HDL-C, LDL-C and TG, respectively. Detailed analysis indicated that 36.9% of this population had at least one type of dyslipidemia and 64.4% had at least one type of abnormal lipid concentration. Thus, this study observed an alarmingly higher prevalence of lipid abnormality, in a relatively large population, compared to previous studies. Further, we determined that not all of the risk factors studied, including age, gender, hypertension, diabetes mellitus, obesity, smoking, drinking, education level, marital status, and family income, influenced dyslipidemia to the same extent.
Our present study, in a population of 11,956 adults in Liaoning Providence, demonstrated a very high prevalence of dyslipidemia, which represented an alarming rise since the publication of our previous study and other similar studies around the world, which report lower levels. We also examined various risk factors for dyslipidemia, many of which are modifiable risk factors for Cardiovascular Disease (CVD), to provide a comprehensive view that will help in designing strategies to slow the rapid spread and promote effective measures to treat dyslipidemia. Our ultimate goal is to prevent the increasing prevalence of lipid abnormality and reduce the burden of CVD in rural China.
Lipids in Health and Disease 12/2014; 13(1):189. DOI:10.1186/1476-511X-13-189 · 2.22 Impact Factor
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Eylem Levelt, Masliza Mahmod, Stefan K. Piechnik, Rina Ariga, Jane M. Francis, Christopher T Rodgers, William T. Clarke, Nikant Sabharwal, Jurgen E. Schneider, Theodoros D. Karamitsos, Kieran Clarke, Oliver J. Rider, Stefan Neubauer
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