Pseudomonas aeruginosa Bacteriophage PA1O Requires Type IV Pili for Infection and Shows Broad Bactericidal and Biofilm Removal Activities

Department of Microbiology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Applied and Environmental Microbiology (Impact Factor: 3.67). 06/2012; 78(17):6380-5. DOI: 10.1128/AEM.00648-12
Source: PubMed


We isolated a new lytic Pseudomonas aeruginosa phage that requires type IV pili for infection. PA1Ø has a broad bactericidal spectrum, covering Gram-positive and Gram-negative bacteria, and can eradicate biofilm cells. PA1Ø may be developed as a therapeutic agent for biofilm-related mixed infections with P. aeruginosa and Staphylococcus aureus.

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