Functional Porphyrin Thin Films Deposited by Matrix Assisted Pulsed Laser Evaporation

Materials Science and Engineering B (Impact Factor: 2.17). 05/2010; 169(1-3). DOI: 10.1016/j.mseb.2010.01.036


We report the first successful deposition of functionalized and nanostructured Zn(II)- and Co(II)-metalloporphyrin thin films by matrix assisted pulsed laser evaporation onto silicon wafers, quartz plates and screen-printed electrodes. The deposited nanostructures have been characterized by Raman spectrometry and cyclic voltammetry. The novelty of our contribution consists of the evaluation of the sensitivity of the MAPLE-deposited Zn(II)- and Co(II)-metalloporphyrin thin films on screen-printed carbon nanotube electrodes when challenged with dopamine.

Download full-text


Available from: Eugenia Fagadar-Cosma, Apr 27, 2015
  • [Show abstract] [Hide abstract]
    ABSTRACT: Modern research is deeply concerned about the interface between synthesis of new chemical structures and obtaining of multifunctional micro- and nano-materials with improved stability and desired properties. It is well-known that in natural life porphyrins and metalloporphyrins are functioning as catalysts, small molecule transporters and optical energy transducers in photosynthesis. The porphyrin based nanomaterials (with tailored optoelectronic, morphological, topological and electrical properties) are designated for advanced optoelectronic devices, especially electrochemical sensors and light harvesting cells and as candidates for second generation photosensitizers in PDT non-invasive treatments. In this chapter, there are presented the new trends in designing of new structures of porphyrins to enhance both their fluorescence and hydrophilicity (emphasizing their use in PDT) and other optoelectronic properties and also the principal classes of nanomaterials based on porphyrins. An overview on porphyrin-inorganic hybrid nanomaterials and a description of bare porphyrin performance in PDT comparatively with that of nanomaterials based on porphyrins as photodynamic therapeutic agents (with a special consideration for self-lighting nanoparticles as active nanoparticles for PDT and on passive colloidal and ceramic based nanoparticles as carriers for porphyrin) was realized. Various strategies for the achievement of nanoscale architectures belonging to different classes of interfaces (porphyrin-silica, porphyrin-metallic, porphyrin-polymeric) are presented along this chapter. A section is designated to hybrid plasmonics represented by silver and gold nanoparticles functionalized with porphyrins and their applications in imaging, gas sensing and construction of photovoltaic cells. Although nanosystems offer amazing medical and technological opportunities however their toxicity should be investigated properly. A new complex and creative research about nanotoxicity of hybrid porphyrin-silica nanomaterials has been initiated by flow cytometric analysis that could provide a rapid and accurate analytical tool for evaluating in vitro biological responses of nanoparticles for nanotoxicology and environmental protection.
  • [Show abstract] [Hide abstract]
    ABSTRACT: We report on thin film deposition of poly(1,3-bis-(p-carboxyphenoxy propane)-co-sebacic anhydride)) 20:80 thin films containing several gentamicin concentrations by matrix assisted pulsed laser evaporation (MAPLE). A pulsed KrF* excimer laser was used to deposit the polymer–drug composite thin films. Release of gentamicin from these MAPLE-deposited polymer conjugate structures was assessed. Fourier transform infrared spectroscopy was used to demonstrate that the functional groups of the MAPLE-transferred materials were not changed by the deposition process nor were new functional groups formed. Scanning electron microscopy confirmed that MAPLE may be used to fabricate thin films of good morphological quality. The activity of gentamicin-doped films against Escherichia coli and Staphylococcus aureus bacteria was demonstrated using disk diffusion and antibacterial drop test. Our studies indicate that deposition of polymer–drug composite thin films prepared by MAPLE is a suitable technique for performing controlled drug delivery. Antimicrobial thin film coatings have several medical applications, including use for indwelling catheters and implanted medical devices.
    Applied Surface Science 04/2011; 257(12):5287-5292. DOI:10.1016/j.apsusc.2010.11.141 · 2.71 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: During the last decade, many groups have grown thin films of various organic materials by the cryogenic Matrix Assisted Pulsed Laser Evaporation (MAPLE) technique with a wide range of applications. This contribution is focused on the summary of our results with deposition and characterization of thin films of fibrinogen, pullulan derivates, azo-polyurethane, cryoglobulin, polyvinyl alcohol, and bovine serum albumin dissolved in physiological serum, dimethyl sulfoxide, sanguine plasma, phosphate buffer solution, H2O, ethylene glycol, and tert-butanol. MAPLE films were characterized using FTIR, AFM, Raman scattering, and SEM. For deposition, a special hardware was developed including a unique liquid nitrogen cooled target holder. Overview of MAPLE thin film applications is given. We studied SnAcAc, InAcAc, SnO2, porphyrins, and polypyrrole MAPLE fabricated films as small resistive gas sensors. Sensors were tested with ozone, nitrogen dioxide, hydrogen, and water vapor gases. In the last years, our focus was on the study of fibrinogen-based scaffolds for application in tissue engineering, wound healing, and also as a part of layers for medical devices.
    Applied Physics A 11/2011; 105(3). DOI:10.1007/s00339-011-6629-0 · 1.70 Impact Factor
Show more