Article

Lactation and maternal subclinical cardiovascular disease among premenopausal women.

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.
American journal of obstetrics and gynecology (impact factor: 3.28). 07/2012; 207(1):46.e1-8. DOI:10.1016/j.ajog.2012.04.030 pp.46.e1-8
Source: PubMed

ABSTRACT The objective of the study was to examine the association between lactation and maternal subclinical cardiovascular disease.
The Women and Infants Study of Healthy Hearts enrolled 607 mothers who delivered a singleton between 1997 and 2002. In 2007, participating mothers underwent measurements of carotid intima-media thickness, lumen diameter, adventitial diameter, and carotid-femoral pulse wave velocity. Multivariable linear and logistic regressions were used to estimate the associations between lactation and subclinical cardiovascular disease.
Compared with mothers who breastfed for 3 or more months after every birth, mothers who never breastfed exhibited a 0.13 mm larger lumen diameter (95% confidence interval, 0.04-0.22) and a 0.12 mm larger adventitial diameter (95% confidence interval, 0.02-0.22) in models adjusting for age, parity, birth outcome, sociodemographic variables, health-related behaviors, family history, gestational weight gain, early adult body mass index, current body mass index, C-reactive protein, blood pressure, cholesterol, triglyceride, high-density lipoprotein, glucose, and insulin levels.
Mothers who do not breastfeed have vascular characteristics associated with a greater risk of cardiovascular disease.

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Keywords

95% confidence interval
 
adult body mass index
 
birth outcome
 
blood pressure
 
C-reactive protein
 
carotid-femoral pulse wave velocity
 
current body mass index
 
gestational weight gain
 
greater risk
 
health-related behaviors
 
Healthy Hearts
 
high-density lipoprotein
 
Infants Study
 
insulin levels
 
lumen diameter
 
maternal subclinical cardiovascular disease
 
Multivariable linear
 
singleton
 
subclinical cardiovascular disease
 
Women