Neuroprotection of the optic nerve in glaucoma
Yale University School of Medicine, New Haven, Conn., USAActa Ophthalmologica Scandinavica (Impact Factor: 1.85). 05/2009; 75(4):364 - 367. DOI: 10.1111/j.1600-0420.1997.tb00391.x
The Journal of Urology 04/2011; 185(4). DOI:10.1016/j.juro.2011.02.2247 · 3.75 Impact Factor
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ABSTRACT: Summary Chronic ischemia of the retina and the optic nerve head seems of importance especially in patients with normal-tension glaucoma (NTG). The purpose of this study was to examine the retinal hemodynamics in patients with NTG. Patients: Twenty-five patients with NTG were examined (3 weeks washout period) in this study (age 58 ± 16 years). The arteriovenous passage (AVP) time and arterial and venous diameters from scanning laser fluorescein angiograms were evaluated by means of digital image analysis. Results: The AVP time in patients with NTG (2.78 ± 1.1 s) was significantly prolonged (P < 0.0001) compared with healthy subjects (1.58 ± 0.4 s). No significant correlation was found between arterial and venous diameters, intraocular pressure, blood pressure or calculated perfusion pressure and retinal arteriovenous passage time. Conclusion: Patients with NTG showed prolonged retinal passage, which could cause chronic hypoxia. This prolongation of circulation is not correlated with any of the clinical parameters. Thus, a circulatory defect might be a primary factor in the pathogenesis of NTG.Der Ophthalmologe 01/1999; 96(1):24-29. DOI:10.1007/s003470050371 · 0.72 Impact Factor
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