A case of uterine adenomyoma with bizarre smooth muscle cells mimicking leiomyosarcoma
ABSTRACT We report a case of adenomyoma of the uterus that was cytologically difficult to distinguish from leiomyosarcoma. Examination of a uterine cervical smear revealed numerous spindle cells that were present in cell clusters or as isolated cells. These cells contained nuclei that were oval-shaped/elongated with nucleoli and delicate wispy cytoplasm. Large and bizarre nuclei were also identified. Based on these cytological findings leiomyosarcoma was considered: however, this diagnosis remained uncertain because of the absence of mitosis and/or necrotic substance. Histologically, we recognized leiomyomatous smooth muscle cells growing in a solid pattern and intermingled with endometrial-type glands. Moreover, bizarre smooth muscle cells were observed in the surface layer of the tumor. These observations suggest that for a diagnosis of uterine leiomyosarcoma the presence of mitosis and/or necrosis is important in addition to nuclear atypia. Diagn. Cytopathol. 2005;32:288–291. © 2005 Wiley-Liss, Inc.
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- "Ectopic adrenal tissue, although common in human pediatric records, is seldom reported in domestic animals, including the dog . In any case, the neoplasm gave the impression of a Mullerian mixed tumour consisting of both mesenchymal and epithelial elements  and more specifically it could be claimed that it shared many common features with neoplasms known as adenomyomas, as described in the human literature . To the authors' knowledge, such case of a uterine leiomyoma containing nonendometrial epithelial foci, associated with adenomyosis and/or cystic endometrial hyperplasia has never been described before. "
ABSTRACT: An 11-year-old Labrador Retriever bitch with a history of intermittent, sanguineous vaginal discharge of a six-month duration was presented. During exploratory laparotomy, two well-delineated, intramural masses were identified bilaterally in the uterine horns. Histopathologic examination of the mass on the left horn showed that it was a typical leiomyoma. However, the second mass appeared with an unusual coexistence of histological lesions, involving epithelial tissue foci, mild focal adenomyosis, and cystic endometrial hyperplasia. Interestingly, such combination was never encountered before in dogs. Although uterine leiomyoma is quite usual in the reproductive system of female dogs, this case resembled relevant cases of human uterine adenomyomas in morphology, and thus it was offered a similar tentative diagnosis.01/2011; 2011. DOI:10.1155/2011/901874
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ABSTRACT: Adenomyomas are circumscribed tumorlike masses most often involving the uterus and consisting of endometrioid glands, stroma, and smooth muscle tissue. They are uncommon in extrauterine sites and in this situation it may be unclear whether such lesions represent foci of endometriosis with marked smooth muscle hyperplasia/metaplasia, uteruslike mass lesions, or leiomyomas with entrapped endometriotic glandular and stromal elements. In this report 2 cases of extrauterine adenomyoma are presented in which the smooth muscle component showed focal atypical (symplastic) cytologic appearances.International journal of gynecological pathology: official journal of the International Society of Gynecological Pathologists 12/2008; 28(1):23-8. DOI:10.1097/PGP.0b013e3181815371 · 1.67 Impact Factor