Article

Impaired regeneration of the peripheral B cell repertoire from bone marrow following lymphopenia in old mice

European Journal of Immunology (Impact Factor: 4.97). 01/2001; 31(2):500 - 505. DOI: 10.1002/1521-4141(200102)31:2<500::AID-IMMU500>3.0.CO;2-C

ABSTRACT Aging is associated with a decreased production of B cells by the bone marrow and an increased life-span of peripheral B cells. To determine whether the decreased bone marrow B cell production is linked to the increased life-span of B cells in old mice, B cell regeneration following lymphopenia was studied in young and old mice. The rate of bone marrow pre-B cell and of splenic B cell regeneration is slower in irradiated, old compared to irradiated, young recipients of young, congeneic bone marrow. This finding reflects an age-associated defect in the bone marrow microenvironment. As the bone marrow is the only source of a diverse population of B cells, we measured the diversity of the splenic B cell repertoire regenerated following drug-induced lymphopenia in old and young mice. The heterogeneity of mRNA size from IgH complementarity determining region 3 (CDR3) was more restricted in splenic B cells from old compared to young mice providing additional evidence for an age-associated impairment in B cell production by the bone marrow.

0 Bookmarks
 · 
59 Views
  • Source
    http://sunzi.lib.hku.hk/hkuto/record/B43703641. 01/2010;
  • [Show abstract] [Hide abstract]
    ABSTRACT: Changes in the antibody repertoire are a well-established feature of immunosenescence. These reflect an aggregate of age-associated alterations in the generation, numbers, and proportions of B-cell subsets; as well as the homeostatic and selective processes governing them. A basic understanding of these relationships, coupled with integrated assessments of how they change with age, should reveal mechanisms underlying the immunosenescent phenotype. Mouse models provide powerful tools for these analyses, allowing controlled manipulation of key genetic, cellular, and microenvironmental factors. Here we summarize current understanding of how primary and antigen-experienced murine B-cell repertoires are established, as well as how they shift with age.
    12/2008: pages 393-413;
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: In this paper, the characteristics of dust-acoustic solitary waves in dusty plasma are studied. Dust charge and temperature are treated as variables. The authors have used the pseudopotential method to investigate the possibility of compressive as well as rarefactive solitons. An expression for the pseudopotential has been derived. The pseudopotential is a function of the Mach number, the relative temperature of low and high ion components, the relative ion concentration of dust charge and the temperature. Numerical computation shows that for the chosen set of parameters, only compressive solitons exist and their amplitudes increase with increasing Mach number. An increase in the dust temperature results in the disappearance of the compressive soliton. It is the only small parameter regime where compressive as well rarefactive solitons coexist. The effect of the relative ion temperature on solitons is also investigated. In the small amplitude limit, an increase in the dust temperature leads to a transition from compressive to rarefactive solitons.
    Journal of Plasma Physics 07/2004; 70(04):481 - 495. · 0.76 Impact Factor

Full-text (2 Sources)

Download
4 Downloads
Available from
Oct 10, 2014