"Bjelland et al., 2003; Kale et al., 2010; Kim et al., 2008; Levine et al., 2002; Muntjewerff et al., 2006), only two studies in PTSD patients exits wherein homocysteine was measured as an indicator of one-carbon metabolism activity. Both studies found higher homocysteine concentrations in male PTSD patients compared to healthy or trauma-exposed controls (Jendricko et al., 2009; Levine et al., 2008). However, in our opinion the available information on the Fig. 1. "
"To date, there are two studies showing the relationship between PTSD and elevated Hcy levels  . However, we failed to find the association between childhood adversities and Hcy levels in FES patients. "
[Show abstract][Hide abstract] ABSTRACT: Objective: It has repeatedly been found that early life traumatic events may contribute to metabolic dysregulation. Therefore, the aim of this study was to investigate the association between the history of childhood trauma and cardiovascular risk factors in first-episode schizophrenia (FES) patients.
Method: The history of childhood trauma was assessed using the Early Trauma Inventory Self Report – Short Form (ETISR-SF) in 83 FES patients. Based on the ETISR-SF, patients were divided into those with positive and negative history of childhood trauma – FES(+) and FES(−) patients. Serum levels of fasting glucose lipids, homocysteine, vitamin B12 and folate, as well as anthropometric parameters, resting systolic and diastolic blood pressure (SBP and DBP) were measured.
Results: The history of childhood trauma was associated with higher LDL levels, SBP and DBP after co-varying for age, gender, BMI, education and chlorpromazine equivalent. There were significant correlations between scores of distinct ETISR-SF subscales and LDL, HDL, SBP, DBP and the number of metabolic syndrome criteria.
Conclusions: Results of this study indicate that traumatic events during childhood might be related to higher resting blood pressure and higher LDL levels in adult FES patients.
General Hospital Psychiatry 03/2015; DOI:10.1016/j.genhosppsych.2015.03.017 · 2.61 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: It is known that elevated serum homocysteine, decreased folate, and low vitamin B12 serum levels are associated with poor cognitive function, cognitive decline, and dementia. Current literature shows that some psychiatric disorders, mainly affective and psychotic ones, can be related to the levels of vitamin B12, folate, and homocysteine. These results can be explained by the importance of vitamin B12, folate, and homocysteine in carbon transfer metabolism (methylation), which is required for the production of serotonin as well as for other monoamine neurotransmitters and catecholamines. Earlier studies focused on the relationship between folate deficiency, hyperhomocysteinemia, and depressive disorders. Although depressive and anxiety disorders show a common comorbidity pattern, there are few studies addressing the effect of impaired one-carbon metabolism in anxiety disorders - especially in obsessive-compulsive disorder (OCD). This study aimed to measure the levels of vitamin B12, folate, and homocysteine specifically in order to see if eventual alterations have an etiopathogenetic significance on patients with OCD. Serum vitamin B12, folate, and homocysteine concentrations were measured in 35 patients with OCD and 22 controls. In addition, the Structured Clinical Interview for the Diagnostic and Statistical Manual for Mental Disorders, Fourth Edition, Text Revision, Yale-Brown Obsessive Compulsive Scale, Hamilton Rating Scale for Depression, and Hamilton Rating Scale for Anxiety were conducted for each patient. It was found that vitamin B12 levels were decreased and homocysteine levels were increased in some OCD patients. Homocysteine levels were positively correlated with Yale-Brown compulsion and Yale-Brown total scores. In conclusion, findings of this study suggest that some OCD patients might have vitamin B12 deficiency and higher homocysteine levels.
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