Point mutations of the BCL‐6 gene in Burkitt's lymphoma

Università degli Studi di Torino, Torino, Piedmont, Italy
British Journal of Haematology (Impact Factor: 4.71). 09/1997; 99(1):168 - 170. DOI: 10.1046/j.1365-2141.1997.3573171.x


BCL-6 codes for a transcription factor implicated in chromosomal translocations of diffuse large cell lymphomas. Recent evidence indicates that BCL-6 may also be altered by mutations of its 5′ non-coding regions. In this study we have investigated the distribution of BCL-6 5′ mutations among 35 Burkitt's lymphoma cases representative of the epidemiologic variants of the disease. Mutations were detected in 6/21 (28.6%) sporadic Burkitt's lymphomas and 7/14 (50%) endemic Burkitt's lymphomas. These data expand the spectrum of B-cell non-Hodgkin's lymphomas associated with BCL-6 5′ mutations and have implications for the pathogenesis, histogenesis and clinical monitoring of Burkitt's lymphoma.

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    • "Expression of BCL6 can also be altered by somatic mutation of the 5¢ non-coding region (Migliazza et al, 1995; Capello et al, 1997; Gaidano et al, 1997; Liang et al, 1997b, 1998; Peng et al, 1999) 2 , and can occur independently of translocation. Some mutations have been shown to significantly deregulate BCL6 expression, whereas others appear functionally irrelevant (Pasqualucci et al, 1998). "
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