ABSTRACT The multiple traditional uses with fewer scientific investigations about C. iners bark made imperative to further exploit this plant for the evaluation of its therapeutic value. Analgesic and antioxidant activities of ethanolic, aqueous and alkaloid extracts prepared from C. iners bark was studied using both in vivo and spectrometric experimental models. Results of hot plate and tail flick studies show that all the screened extracts are devoid of central analgesic activity. However, promising findings regarding the peripheral analgesic and anti-inflammatory activity was revealed from the formalin induced pain method with alkaloid extract possessing significant activity followed by ethanolic and aqueous extract. Moreover, the results of total phenolic content and antioxidant activity was also confirmed the presence of higher amount polyphenolic content in ethanolic extract with significant antioxidant activity. The observed peripheral analgesic activity by ethanolic and aqueous extract might be due to the presence of higher amount polyphenolic present in them. Results of this study also supported the traditional use of this plant in the treatment of pain. Hence, it was concluded from the study that C. iners bark extract can be utilized as new source of peripheral analgesic in the treatment of pain.