From material to tissue: Biomaterial development, scaffold fabrication, and tissue engineering

Dept. of Chemical and Biomolecular Engineering, Rice University, Houston, TX 77251
AIChE Journal (Impact Factor: 2.49). 10/2008; 54(12):3048 - 3067. DOI:10.1002/aic.11610

ABSTRACT The need for techniques to facilitate the regeneration of failing or destroyed tissues remains great with the aging of the worldwide population and the continued incidence of trauma and diseases such as cancer. A 16-year history in biomaterial scaffold development and tissue engineering is examined, beginning with the synthesis of novel materials and fabrication of 3D porous scaffolds. Exploring cell-scaffold interactions and subsequently cellular delivery using biomaterial carriers, we have developed a variety of techniques for bone and cartilage engineering. In addition to delivering cells, we have utilized growth factors, DNA, and peptides to improve the in vitro and in vivo regeneration of tissues. This review covers important developments and discoveries within our laboratory, and the increasing breadth in the scope of our work within the expanding field of tissue engineering is presented. © 2008 American Institute of Chemical Engineers AIChE J, 2008

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    ABSTRACT: Our laboratory at Rice University has forged numerous collaborations with clinicians and basic scientists over the years to advance the development of novel biomaterials and the modification of existing materials to meet clinical needs. This review highlights collaborative advances in biomaterials research from our laboratory in the areas of scaffold development, drug delivery, and gene therapy, especially as related to applications in bone and cartilage tissue engineering.
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James D Kretlow