Article

Retroperitoneal paraganglioma manifesting as paralytic ileus: a case report.

Division of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan. .
Journal of Medical Case Reports 06/2012; 6(1):158. DOI: 10.1186/1752-1947-6-158
Source: PubMed

ABSTRACT Retroperitoneal neoplasms are rare and easily misdiagnosed. These tumors are often discovered incidentally during imaging studies performed for other reasons. Paragangliomas are tumors that arise from extra-adrenal medullary neural crest derivatives. They are usually located in the head and neck but can be found in various body sites, including the chest cavity, abdomen, pelvis and bladder. We report the case of a patient who had a retroperitoneal paraganglioma manifested as paralytic ileus, which is an unusual presentation of a paraganglioma.
A 63-year-old Taiwanese woman was admitted to the emergency department of our hospital with progressive abdominal fullness for two days. Her medical history included medically controlled hypertension for 10 years and type 2 diabetes mellitus. Plain abdominal radiography showed a solitary loop of the air-filled dilated small bowel. Abdominal computed tomography did not show a mechanical obstruction; however, a retroperitoneal mass was incidentally detected. Histological analysis of the mass led to a diagnosis of a paraganglioma.
In cases of patients with hypertension presenting with an intestinal pseudo-obstruction, a paraganglioma may be considered as a possible differential diagnosis of retroperitoneal tumors to avoid risky therapeutic procedures or medication that may produce severe adverse effects.

0 Bookmarks
 · 
91 Views
  • Herz 02/2014; · 0.78 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Hereditary paraganglioma-pheochromocytoma syndromes (PGL/PCC) are rare tumours arising from neuroendocrine cells. The proband, a 59 year old Caucasian male and his 42 year old elder son had a past history of bilateral carotid body paraganglioma and both presented for treatment of abdominal paragangliomas. His 36 year old daughter had excision of recurrent malignant carotid body paraganglioma and vertebral metastasis. His 33 year old youngest son presented for excision of unilateral carotid body paraganglioma. All four members had SDHD mutation, whilst the proband and youngest son also had concurrent RET mutation. This is the first report of PGL/PCC with SDHD and RET mutations. The role of the RET gene as a modifier remains speculative. Additionally, the family pedigree suggests maternal inheritance of disease from the probands' paternal grandmother. Clinicians should refer PGL/PCC families for mutation analysis as well as be alert to changes in classification of mutations. Head Neck, 2013.
    Head & Neck 12/2013; · 2.83 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Paragangliomas are tumors that originate from extra-adrenal medullary neural crest derivatives. They are rarely located in retroperitoneal space. These tumors are often discovered incidentally during imaging studies performed for other reasons. Periampullary cancers include adenocarcinomas arising from the pancreas, ampulla of Vater, duodenum or distal common bile duct. The exact site of origin of periampullary tumors is often difficult to ascertain pre-operatively. We report the case of a patient who had a retroperitoneal non-functional paraganglioma, concurrent with periampullary adenocarcinoma. An 81-year-old woman was admitted with progressive abdominal fullness. There was an upper paramedian, left sided, large, palpable mass on the physical examination. Laboratory investigations showed an increase in liver enzyme levels. On abdominal computed tomography the patient found to have a large retroperitoneal mass and dilation in biliary tract, which was confirmed by magnetic resonance cholangiopancreatography. She had a tumoral papi in Endoscopic Retrograde cholangiopancreatography. Which biopsy revealed adenocarcinoma. She underwent surgery for excision of abdominal mass and pancreaticoduodenectomy. And pathologic study showed paraganglioma. This is the first ever reported case of concurrent paraganglioma and periampullary adenocarcinoma.
    Journal of research in medical sciences 12/2013; 18(12):1114-6. · 0.68 Impact Factor

Full-text

View
1 Download
Available from