Maturity‐onset diabetes of the young (MODY)

Department of Internal Medicine (Division of Endocrinology and Metabolism), University of Michigan Medical Center, Ann Arbor, Michigan 48109
Diabetes / Metabolism Reviews 11/1989; 5(7):579 - 606. DOI: 10.1002/dmr.5610050705
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    ABSTRACT: Fibrocalculous Pancreatic Diabetes (FCPD) is a form of diabetes s econdary to tropical chronic pancreatitis . While majority of patients have onset of diabetes in youth childhood onset FCPD is less common. We found that 10.8% of diabetic with onset below 20 years of age had FCPD. The clinical features of childhood onset FCPD w ere similar to older age group patients. FCPD must be kept i n mind in the differential diagnosis of childhood onset diabetes in geographical areas where this entity is common.
  • Nutrition 03/1997; 13(2):95-9. DOI:10.1016/S0899-9007(96)00398-X · 3.05 Impact Factor
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    ABSTRACT: The Hepatocyte Nuclear Factors Hepatocyte nuclear factors are a diverse class of transcription factors that were originally identified through their interaction with essential sequences for tissue-specific transcription of liver specific genes. These factors contain DNA-binding domains that have been conserved throughout evolution. Based on the structure of their functional domains, liver-enrichedtranscriptionfactors have been classified into six families. These include HNF-1 [HNF-1α and HNF-1β (vHNF-1)] genes, members of the homeodomaincontaining transcription factors; CCAAT/enhancer binding proteins (C/EBPs) that are basic leucine-zipper transcription factors; the winged helix proteins HNF-3 [HNF-3α, HNF-3β and HNF-γ], members of the HNF-3/forkhead(bZip) transcription factor family; the zinc finger orphan receptor HNF-4 family [HNF-4α and HNF-4β]; D-binding protein [DBP], a member of the proline acid-rich (PAR) subfamily of bZip transcription factors; and HNF-6, which contains two different DNA binding domains, a cut domain and a novel type of homeodomain.
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