[Show abstract][Hide abstract] ABSTRACT: Fibrocalculous Pancreatic Diabetes (FCPD) is a form of diabetes s econdary to tropical chronic pancreatitis . While majority of patients have onset of diabetes in youth childhood onset FCPD is less common. We found that 10.8% of diabetic with onset below 20 years of age had FCPD. The clinical features of childhood onset FCPD w ere similar to older age group patients. FCPD must be kept i n mind in the differential diagnosis of childhood onset diabetes in geographical areas where this entity is common.
[Show abstract][Hide abstract] ABSTRACT: The Hepatocyte Nuclear Factors Hepatocyte nuclear factors are a diverse class of transcription factors that were originally
identified through their interaction with essential sequences for tissue-specific transcription of liver specific genes. These
factors contain DNA-binding domains that have been conserved throughout evolution. Based on the structure of their functional
domains, liver-enrichedtranscriptionfactors have been classified into six families. These include HNF-1 [HNF-1α and HNF-1β
(vHNF-1)] genes, members of the homeodomaincontaining transcription factors; CCAAT/enhancer binding proteins (C/EBPs) that
are basic leucine-zipper transcription factors; the winged helix proteins HNF-3 [HNF-3α, HNF-3β and HNF-γ], members of the
HNF-3/forkhead(bZip) transcription factor family; the zinc finger orphan receptor HNF-4 family [HNF-4α and HNF-4β]; D-binding
protein [DBP], a member of the proline acid-rich (PAR) subfamily of bZip transcription factors; and HNF-6, which contains
two different DNA binding domains, a cut domain and a novel type of homeodomain.
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