Article

Potential application of non-small cell lung cancer-associated autoantibodies to early cancer diagnosis.

Tianjin Lung Cancer Institute, Tianjin General Hospital, Tianjin Medical University, Tianjin 300070, China.
Biochemical and Biophysical Research Communications (impact factor: 2.48). 06/2012; 423(3):613-9. DOI:10.1016/j.bbrc.2012.06.050 pp.613-9
Source: PubMed

ABSTRACT To identify a panel of tumor associated autoantibodies which can potentially be used as biomarkers for the early diagnosis of non-small cell lung cancer (NSCLC). Thirty-five unique and in-frame expressed phage proteins were isolated. Based on the gene expression profiling, four proteins were selected for further study. Both receiver operating characteristic curve analysis and leave-one-out method revealed that combined measurements of four antibodies produced have better predictive accuracies than any single marker alone. Leave-one-out validation also showed significant relevance with all stages of NSCLC patients. The panel of autoantibodies has a high potential for detecting early stage NSCLC.

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Keywords

antibodies
 
autoantibodies
 
characteristic curve analysis
 
combined measurements
 
detecting
 
gene expression profiling
 
in-frame
 
leave-one-out method
 
Leave-one-out validation
 
non-small cell lung cancer
 
significant relevance
 
single marker