Partition coefficients of ketones, phenols, aliphatic and aromatic acids, and esters in n-hexane/nitromethane
ABSTRACT Liquid-liquid partition is used in sample preparation and in countercurrent and liquid-liquid chromatographic separations.
Partition coefficients are widely used in toxicology, environmental, and analytical chemistry. The K
determination procedure for the n-hexane/nitromethane system was optimized and partition coefficients for 99 ketones, esters and trimethylsilyl derivatives
of phenols, aliphatic and aromatic acids were determined. For 130 compounds, K
values were predicted using mathematical relationships between K
and other physicochemical and structural parameters.
KeywordsPartition coefficients–n-Hexane/nitromethane system–Structure-partitioning relationships
- Octanol-Water Partition Coefficients: Fundamentals and Physical Chemistry..