PASS-assisted exploration of new therapeutic potential of natural products

Medicinal Chemistry Research (Impact Factor: 1.61). 04/2011; 20(9):1509-1514. DOI: 10.1007/s00044-010-9398-y

ABSTRACT The use of drug substances derived from plants, fungi, bacteria, and marine organisms are “Mother Nature Gift” for diseases
of mankind. Many of these are discovered serendipitously and have a long tradition in medicine. Till date, the use of natural
products, their semisynthetic and synthetic derivatives have been mostly confined to their ethnic use. But it has been well
known that each substance has a wide spectrum of biological activities as evident from some new uses of many old drugs. PASS
(Prediction of Activity Spectra for Substances) has been employed as a strong potential tool to predict the biological activity
spectrum of synthetic substances for the discovery of new drugs. But the potential of PASS to predict the biological activity
spectra of natural products is still underestimated. The present study was therefore undertaken to investigate and correlate
the biological activity spectrum of the main phytoconstituent of some selected Indian medicinal plants with their reported
biological activities in order to evaluate the applicability of PASS. Further, the unexplored but PASS-predicted activities
having good activity score (Pa>0.7) for particular structure were listed as hidden potential of the plant.

KeywordsAyurveda–Biological activity spectrum–Herbal drugs–Natural products–PASS

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