Rôle du pathologiste dans l’évaluation histopathologique de la réponse à la chimiothérapie néoadjuvante dans le cancer du sein: mise au point

Journal africain du cancer / African Journal of Cancer 02/2010; 2(1):33-35. DOI: 10.1007/s12558-010-0063-7


La chimiothérapie néoadjuvante est de plus en plus utilisée dans la séquence thérapeutique des cancers du sein. Certains pathologistes
se sont intéressés aux altérations cytologiques et histologiques produites par les cytotoxiques sur le tissu mammaire tumoral
ou non et sur les ganglions lymphatiques. Des classifications histologiques se proposant de quantifier la réponse à la chimiothérapie
ont vu le jour. L’objectif de ce travail est de mettre le point sur ces classifications et d’éclairer le rôle de l’anatomopathologiste
dans l’évaluation histopathologique de la réponse à la chimiothérapie néoadjuvante dans le cancer du sein.

The neoadjuvant chemotherapy is more and more used in the therapeutic sequence of breast cancer. Several pathologists were
interested in cytological and histological effects of chemotherapy on tumoral and nonneoplastic breast tissue and on lymphatic
nodes. Histological classifications had been proposed and used in the valuation of these effects. The purpose of this study
is to review these classifications and to enlighten the role of pathologists in the histopathological valuation of response
to the neoadjuvant chemotherapy in breast cancer.

Mots clésCancer du sein-Chimiothérapie néoadjuvante-Classification histologique
KeywordsBreast cancer-Neoadjuvant chemotherapy-Histological classification

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