Article

Granulocyte-colony stimulating factor-producing esophageal carcinosarcoma: a case report

Esophagus (impact factor: 0.66). 04/2012; 4(3):117-120. DOI:10.1007/s10388-007-0113-0 pp.117-120

ABSTRACT An 80-year-old man presented at our hospital with chest oppression and vomiting. An endoscopic examination revealed a tumor
in the lower portion of the esophagus, and the patient was diagnosed as possibly having esophageal carcinosarcoma based on
a histological examination of endoscopic biopsy specimens. During the initial medical examination, the patient had a high
leukocyte count and a high level of serum granulocyte-colony stimulating factor (G-CSF). Moreover, immunohistochemical examination
revealed cells that were positive for antibodies against G-CSF. Therefore, we diagnosed the patient as possibly having a G-CSF-producing
esophageal carcinosarcoma. The patient died of tumor 4 months after the initial diagnosis.

0 0
 · 
0 Bookmarks
 · 
53 Views
  • Source
    Article: An esophageal squamous cell carcinoma patient with high serum granulocyte-colony stimulating factor level: report of a case
    Tadashi Tanabe, Tatsuo Kanda, Noriko Ishihara, Shin-ichi Kosugi, Atsushi Matsuki, Gen Watanabe, Ryuta Sasamoto, Katsuyoshi Hatakeyama
    [show abstract] [hide abstract]
    ABSTRACT: We present herein a case of a patient who was clinically diagnosed as having a granulocyte-colony stimulating factor (G-CSF)-producing tumor on the basis of the close correlation of the hematological parameters with the tumor status and his high serum G-CSF level. A 76-year-old male patient underwent transthoracic radical esophagectomy for advanced carcinoma of the lower esophagus. His leukocyte count and serum G-CSF level were markedly high at 24 260/μl and 134 pg/ml, respectively, before the operation. By immunohistochemical staining of the resected tumor, focal but obvious expression of G-CSF was demonstrated in the cytoplasm of cancer cells, and neutrophilic infiltration was histologically observed in adjacent struma of the tumor invasion front. After surgery, the leukocyte count decreased to a nearly normal level but increased again when the disease recurred in the pleura and lymph nodes 5 months later. Although palliative chemoradiotherapy decreased the leukocyte count to a normal level transiently, leukocyte count again markedly increased when metastatic disease occurred. The leukocyte count reached 78 060/μl the day before the patient died.
    Esophagus 04/2012; 6(4):253-258. · 0.66 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

80-year-old man
 
antibodies
 
chest oppression
 
endoscopic biopsy specimens
 
endoscopic examination
 
esophageal carcinosarcoma
 
histological examination
 
immunohistochemical examination
 
initial diagnosis
 
initial medical examination
 
leukocyte count
 
lower portion
 
serum granulocyte-colony stimulating factor
 
tumor 4 months