Chapter

PET Imaging of Response and Resistance to Cancer Therapy

DOI: 10.1007/978-1-59745-035-5_5

ABSTRACT As cancer treatment moves towards more targeted therapy, there is an increasing need for tools to guide therapy selection
and to evaluate response. Biochemical and molecular imaging can complement existing in vitro assay methods and is likely to
play a key role in early drug testing and development, as well as future clinical practice. Imaging is ideally suited to assessing
the spatial and temporal heterogeneity of cancer and to measure in vivo drug effects. This chapter highlights imaging approaches
to guide cancer therapy, focusing on positron emission tomography and on those approaches that have undergone preliminary
testing in patients. Examples showing how positron emission tomography imaging can be used to (1) assess the therapeutic target,
(2) identify resistance factors, and (3) measure early response are described.

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