Baboons in Drug Abuse Research
Baboons and other nonhuman primates have come to play an increasingly important role over the past 30 years as experimental
subjects in the area of drug abuse research due to their extensive physiological, anatomical, and behavioral similarities
to humans. Compared with other Old World monkeys, the relatively large size of baboons originally made them ideal subjects
for drug self-administration and chronic intragastric drug administration studies requiring indwelling catheters. Such studies
resulted in the seminal finding of a high concordance between those psychoactive drugs that are self-administered by baboons
and those that are abused by humans (Brady et al., 1987, 1990).
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