Baboons in Drug Abuse Research

DOI: 10.1007/978-0-387-75991-3_16

ABSTRACT Baboons and other nonhuman primates have come to play an increasingly important role over the past 30 years as experimental
subjects in the area of drug abuse research due to their extensive physiological, anatomical, and behavioral similarities
to humans. Compared with other Old World monkeys, the relatively large size of baboons originally made them ideal subjects
for drug self-administration and chronic intragastric drug administration studies requiring indwelling catheters. Such studies
resulted in the seminal finding of a high concordance between those psychoactive drugs that are self-administered by baboons
and those that are abused by humans (Brady et al., 1987, 1990).

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    ABSTRACT: Baboons were trained to ingest ethanol at successively higher ethanol concentrations using oral self-administration techniques. Concurrently, animal psychophysical procedures were employed to determine auditory thresholds and reaction times daily. Maximal consumption of ethanol occurred at concentrations of 6-8% (w/v). During the initial period of ethanol self-administration, both auditory reaction times and auditory thresholds became elevated as animals consumed larger amounts of ethanol. For both the threshold and reaction time measures, the degree of elevation was correlated with the amount of ethanol consumed. These correlations decreased, however, with continued ethanol consumption. The elevations in sensory and motor function recovered to near-baseline levels when ethanol was no longer available.
    Drug and Alcohol Dependence 01/1990; 24(3):213-25. · 3.14 Impact Factor
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    ABSTRACT: The effects of morphine and buprenorphine on auditory perceptual discriminations and response latency ("reaction time") in baboons are compared. The task employed synthetic human vowel sounds that are readily generated in the laboratory, and closely approximate natural baboon "grunt" vocalizations [J. Acoust. Soc. Am. 101 (1997) 2951]. Baboons pressed a lever to produce one repeating "standard" vowel, and released the lever only when one of four other "comparison" vowels occasionally occurred in place of the standard vowel. The percentage of correct detections and median reaction time for each comparison were measured following intramuscular drug administrations of morphine (0.01-1.8 mg/kg) and buprenorphine (0.00032-0.032 mg/kg). Both morphine and buprenorphine impaired vowel discriminability, and greater impairments occurred for those comparison vowels that were more similar in formant structure to the standard vowel. Morphine increased reaction time in all baboons, and buprenorphine increased reaction time in two of three baboons. Morphine's perceptual effects occurred within 20-40 min following drug administration; buprenorphine's perceptual effects occurred 50-100 min following drug administration. Morphine and buprenorphine did not differ in the time course of their maximal reaction time effects. The results demonstrate that both morphine and buprenorphine can impair auditory discriminations involving human vowel sounds in baboons, as well as lengthen reaction times to the stimuli.
    Pharmacology Biochemistry and Behavior 01/2001; 69(1-2):305-13. · 2.82 Impact Factor
  • 01/1987;