Diphenyl diselenide supplementation delays the development of N-nitroso-N-methylurea-induced mammary tumors

Archive für Toxikologie (Impact Factor: 5.22). 09/2008; 82(9):655-663. DOI: 10.1007/s00204-007-0271-9

ABSTRACT The effect of dietary diphenyl diselenide (1ppm) on N-nitroso-N-methylurea (NMU)-induced mammary carcinogenesis was examined in female Wistar rats. Beginning at 5weeks of age, the animals
were fed with either control or diphenyl-diselenide-supplied diets until the end of the study (210days). At 50days of age,
mammary tumor was induced by the administration of three doses of NMU (50mg/kg body wt, intraperitoneally) once a week for
3weeks. In experimental trials, latency to tumor onset was extended in rats fed with diet supplemented with diphenyl diselenide
(P<0.05). The incidence and frequency of tumors were significantly small in animals supplemented with diphenyl diselenide.
However, the multiplicity of tumors was not altered by dietary diphenyl diselenide. Diphenyl diselenide supplementation also
restored superoxide dismutase (SOD) activity and vitamin C levels altered in the NMU group (P<0.05). Our results suggest that diphenyl diselenide can be considered a chemopreventive agent, even when supplemented at
a relatively low concentration.

  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Cognitive deficits have been observed in different animal models of adult-onset hypothyroidism. Thus, this study was delineated to evaluate whether diphenyl diselenide, an organoselenium compound with neuroprotective and antioxidant properties, could afford protection against the detrimental effects of hypothyroidism on behavioral parameters. Hypothyroidism condition was induced in female rats by continuous exposure to methimazole (MTZ) at 20 mg/100 ml in the drinking water, during 3 months. MTZ-induced hypothyroid rats were fed with either standard or a diet containing 5 ppm of diphenyl diselenide for 3 months. Behavioral assessments were performed monthly, in the following order: elevated plus maze, open field and Morris water maze. The levels of thyroid hormones in the animals exposed to MTZ were lower than control until the end of experimental period. The rats exposed to MTZ had a significant weight loss from the first month, which was not modified by diphenyl diselenide supplementation. In elevated plus maze test, MTZ exposure caused a reduction on the number of entries of animals in closed arms, which was avoided by diphenyl diselenide supplementation. In Morris water maze, the parameters latency to reach the platform and distance performed to find the escape platform in the test session were significantly greater in MTZ group when compared to control. These cognitive deficits observed in MTZ-induced hypothyroid rats were restored by dietary diphenyl diselenide. The group fed with diphenyl diselenide alone exhibited a better spatial learning and memory capability in some parameters of Morris water maze when compared to the control group. In summary, our data provide evidence of the effectiveness of dietary diphenyl diselenide in improving the performance of control and hypothyroid rats in the water maze test.
    International journal of developmental neuroscience: the official journal of the International Society for Developmental Neuroscience 04/2012; 30(2):83-9. · 2.03 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Oxidative stress caused by reactive species, including reactive oxygen species, reactive nitrogen species, and unbound, adventitious metal ions (e.g., iron [Fe] and copper [Cu]), is an underlying cause of various neurodegenerative diseases. These reactive species are an inevitable by-product of cellular respiration or other metabolic processes that may cause the oxidation of lipids, nucleic acids, and proteins. Oxidative stress has recently been implicated in depression and anxiety-related disorders. Furthermore, the manifestation of anxiety in numerous psychiatric disorders, such as generalized anxiety disorder, depressive disorder, panic disorder, phobia, obsessive-compulsive disorder, and posttraumatic stress disorder, highlights the importance of studying the underlying biology of these disorders to gain a better understanding of the disease and to identify common biomarkers for these disorders. Most recently, the expression of glutathione reductase 1 and glyoxalase 1, which are genes involved in antioxidative metabolism, were reported to be correlated with anxiety-related phenotypes. This review focuses on direct and indirect evidence of the potential involvement of oxidative stress in the genesis of anxiety and discusses different opinions that exist in this field. Antioxidant therapeutic strategies are also discussed, highlighting the importance of oxidative stress in the etiology, incidence, progression, and prevention of psychiatric disorders.
    Current Neuropharmacology 03/2014; 12(2):120-39. · 2.03 Impact Factor

Full-text (2 Sources)

Available from
Jun 11, 2014