Age-related macular degeneration in the eye of a 91-year-old man was studied histologically. Typical of this disease, which
manifests as death of central photoreceptors, were dystrophic changes of the retinal pigment epithelium (RPE) and neural retina.
Also typical were increased drusen deposits, which accumulated between the RPE basement membrane and the inner layer of Bruch's
membrane, and choroidal neovascularization. We histologically observed and demonstrated a subclinical neovascularization that
fluorescein angiography did not.
[Show abstract][Hide abstract] ABSTRACT: Clinical and pathological examination was performed on 378 eyes from 216 patients aged 43 to 97 years. This series represented eyes in which the fundi were normal or showed various manifestations of senile macular degeneration. The eyes were divided into six groups according to the histological appearance of a linear deposit at the base of the retinal pigment cells. Groups I and II were considered to represent normal ageing, Groups III and IV the progressive development of senile macular degeneration, and Groups V and VI the end-results.
British Journal of Ophthalmology 06/1976; 60(5):324-41. DOI:10.1136/bjo.60.5.324 · 2.98 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Tissue obtained from the macula in 10 human eyes (53-77 years) was used for an investigation into the extracellular matrices of the retinal pigment epithelium (RPE), Bruch's membrane, and the choriocapillaris. The ultrastructural distribution of type IV collagen and laminin was documented using immunogold labelling. Labelling for type IV collagen was strongly positive in all the specimens in the basement membranes of the choriocapillaris but not that of the RPE where labelling was either weak or absent. Laminin was localised to deposits of granular material in Bruch's membrane but was absent from the basement membrane of the RPE and the choriocapillaris. Basal linear deposit, observed in three cases, demonstrated labelling for laminin but not for type IV collagen. The series was too small for correlation of these morphological changes with age.
British Journal of Ophthalmology 11/1992; 76(10):607-14. DOI:10.1136/bjo.76.10.607 · 2.98 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.