The diagnosis and management of syphilis in the HIV-infected patient
In the 1980s, the number of cases of syphilis in the United States increased concurrently with the onset of the HIV epidemic.
Within a short time, clinicians began to note unusual presentations of syphilis and inappropriate responses to standard therapy
for syphilis in dually infected patients. Whether these cases collectively represented a new aspect of the natural history
of syphilis remains to be elucidated. In recent years, only a few prospective studies have addressed this issue, and the results
of these studies have been inconclusive.
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